Basic Information - Original Data

Calabria

Dataset statistics
Number of observations 144
Number of variables 382

Humanitas

Dataset statistics
Number of observations 505
Number of variables 251

Italian

Dataset statistics
Number of observations 1151
Number of variables 139

Drop qualitative variables with only one category

Categorical variables with just one factor or category will be detected and removed because do not provide useful information.

Calabria

Variables Description
redcap_event_name Event Name
redcap_repeat_instrument Repeat Instrument
country Country
corona_ieorres Suspected or confirmed novel coronavirus (COVID-19) infection:
symptoms_epi_animal 6.Direct contact with animals in countries where the nCoV is known to be circulating in animal populations or where human infections have occurred as a result of presumed zoonotic transmission
ethnic___5 Ethnic group (choice=West Asian)
ethnic___8 Ethnic group (choice=Aboriginal/First Nations)
ethnic___9 Ethnic group (choice=Other)
ethnic___10 Ethnic group (choice=N/A)
labwork_erterm Employed in a microbiology laboratory?
age_estimateyearsu Age Unit
postpart_rptestcd Post Partum?
apdm_age INFANT - Less than 1 year old?
apvs_weightu Birth weight unit
apsc_gestout Gestational outcome
apsc_brfed Breastfed?
apsc_vcageind Vaccinations appropriate for age/country?
travel_erterm 2.6 Travel in the 14 days prior to first symptom onset?
supper_trcntry 2.6.1 If YES, state location: Country
travel_erterm_2 2.6.4 Travelled to another country in the 14 days prior to first symptom onset?
animal_eryn 2.7 Contact with animals, raw meat or insect bites in the 14 days prior to symptom onset?
temp_vsorresu Temperature Units
weight_vsorresu Weight Unit
coughhb_ceoccur_v2 4a.2.2 Cough: bloody sputum / haemoptysis
earpain_ceoccur_v2 4a.5. Ear pain
lowerchest_ceoccur_v2 Lower chest wall indrawing
conjunct_ceoccur_v2 Conjunctivitis
lymp_ceoccur_v2 Lymphadenopathy
ageusia_ceoccur_v2 Loss of taste (Ageusia)
skinulcers_ceoccur_v2 4a.20. Skin ulcers
bleed_ceterm_v2 4a.23. If Bleeding (others)
pre_antiviral_cmoccur Antivirals
aidshiv_mhyn_2 AIDS / HIV
aidshiv_mhyn 4b.10. AIDS/HIV
daily_temp_vsorresu Temperature Unit
daily_sa02_lbyn 1.3 SaO2 available?
daily_stercap_vsorres Sternal capillary refill time >2 seconds?
daily_noninvasive_prtype Non-invasive ventilation - if YES:
daily_nitritc_cmtrt Inhaled Nitric Oxide?
daily_trach_prperf Tracheostomy inserted?
daily_ecmo_prtrt Extra corporeal life support (ECLS / ECMO)?
daily_rrt_cmtrt Renal replacement therapy (RRT) or dialysis?
daily_dopless5_cmtrt Dopamine < 5 µg/kg/min OR Dobutamine OR milrinone OR levosimendan:
daily_prperf Other intervention(s) or procedure(s)?
daily_pao2_lborresu PaO2 unit:
daily_pao2_lbspec PaO2 sample type
daily_pco2_lborresu PCO2 Unit
daily_hco3_lborresu HCO3- Unit
daily_lbperf Are any laboratory results avavailable on this day?
daily_hb_lborresu Haemoglobin Unit
daily_wbc_lborresu WBC Unit
daily_lymp_lborresu Lymphocyte Unit
daily_neutro_lborresu Neutrophil Unit
daily_haematocrit_lborresu Haematocrit Unit
daily_plt_lborresu Platelets Unit
daily_alt_lborresu ALT/SGPT Unit
daily_bil_lborresu Total Bilirubin Unit
daily_ast_lborresu AST/SGOT Unit
daily_glucose_lborresu Glucose Unit
daily_bun_lborresu Urea (BUN) Unit
daily_lactate_lborresu Lactate Unit
daily_creat_lborresu Serum Creatinine Unit
daily_sodium_lborresu Sodium Unit
daily_potassium_lborresu Potassium Unit
daily_procal_lborresu Procalcitonin Unit
daily_crp_lborresu CRP Unit
daily_ldh_lborresu LDH Unit
daily_crekin_lborresu Creatine kinase Unit
daily_troponin_lborresu Troponin I Unit
daily_ddimer_lborresu D-dimer Unit
daily_ferritin_lborresu Ferritin Unit
daily_il6_lborresu IL-6 Unit
xray_prperf X-ray performed?
inhalednit_cmtrt Inhaled Nitric Oxide sometime?
extracorp_prtrt Extracorporeal support (ECMO)?
rrt_prtrt Renal replacement therapy (RRT) or dialysis?
other_cmyn 6.8 OTHER intervention or procedure
cryptogenic_ceterm Cryptogenic organizing pneumonia (COP)
bronchio_ceterm Bronchiolitis
cardiacarrest_ceterm Cardiac arrest
myocardial_ceterm Myocardial infarction
ischaemia_ceterm Cardiac ischemia
myocarditis_ceterm Myocarditis/Pericarditis
endocarditis_ceterm Endocarditis
seizure_ceterm Seizure
stroke_ceterm Stroke / Cerebrovascular accident
meningitis_ceterm Meningitis / Encephalitis
endocarditis_aeterm 4c.12. Endocarditis / Myocarditis / Pericarditis
pancreat_ceterm Pancreatitis
ceterm_clin_dx Was patient clinically diagnoses with COVID-19?
mbperf Was pathogen testing done during this illness episode?
corna_mbcat Coronavirus:
corna_mbcaty Coronavirus - if Positive:
influ_mbyn Influenza:
rsv_mbcat RSV
adeno_mbcat Adenovirus
daily_mbperf Pathogen testing done
mbspec Biospecimen type
mbmethod Laboratory Test Method
mborres Result
antiviral_cmtrt___1 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Ribavirin)
antiviral_cmtrt___5 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Neuraminidase inhibitors)
antiviral_cmtrt___3 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Interferon alpha)
antiviral_cmtrt___4 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Interferon beta)
corticost_cmroute___4 Corticosteroid - if YES, Route: (choice=Unknown)
heparint_cmroute___2 Heparin - if YES, Route: (choice=Intravenous (IV))
heparint_cmroute___3 Heparin - if YES, Route: (choice=Unknown)
renal_proccur 7.3.3. Dialysis / renal treatment?
other_cmoccur 7.3.4. Other intervention or procedure?
siteid 7.4.1. If Transferred: Facility name

Humanitas

Variables Description
country Country
ethnic___1 Ethnic group (choice=Arab)
ethnic___2 Ethnic group (choice=Black)
ethnic___3 Ethnic group (choice=East Asian)
ethnic___4 Ethnic group (choice=South Asian)
ethnic___5 Ethnic group (choice=West Asian)
ethnic___8 Ethnic group (choice=Aboriginal/First Nations)
ethnic___9 Ethnic group (choice=Other)
ethnic___10 Ethnic group (choice=N/A)
labwork_erterm Employed in a microbiology laboratory?
age_estimateyearsu Age Unit
pregyn_rptestcd Pregnant?
temp_vsorresu Temperature Units
weight_vsorresu Weight Unit
conjunct_ceoccur_v2 Conjunctivitis
lymp_ceoccur_v2 Lymphadenopathy
seizures_cecoccur_v2 Seizures
anorexia_ceoccur_v2 Anorexia
rash_ceoccur_v2 Skin rash
other_ceoccur_v2 Other sign or symptom
pre_nsaid_cmoccur Non-steroidal anti-inflammatory (NSAID)
pre_othmed_cmoccur Other targeted COVID-19 Medications
asplenia_mhyn Asplenia
tb_mhyn Tuberculosis
malnutrition_mhyn Malnutrition
other_mhyn Other relevant risk factor(s)
daily_nitritc_cmtrt Inhaled Nitric Oxide?
daily_trach_prperf Tracheostomy inserted?
daily_prperf Other intervention(s) or procedure(s)?
daily_pao2_lborresu PaO2 unit:
daily_pco2_lborresu PCO2 Unit
daily_hco3_lborresu HCO3- Unit
daily_hb_lborresu Haemoglobin Unit
daily_wbc_lborresu WBC Unit
daily_lymp_lborresu Lymphocyte Unit
daily_neutro_lborresu Neutrophil Unit
daily_haematocrit_lborresu Haematocrit Unit
daily_plt_lborresu Platelets Unit
daily_alt_lborresu ALT/SGPT Unit
daily_bil_lborresu Total Bilirubin Unit
daily_ast_lborresu AST/SGOT Unit
daily_glucose_lborresu Glucose Unit
daily_bun_lborresu Urea (BUN) Unit
daily_lactate_lborresu Lactate Unit
daily_creat_lborresu Serum Creatinine Unit
daily_sodium_lborresu Sodium Unit
daily_potassium_lborresu Potassium Unit
daily_procal_lborresu Procalcitonin Unit
daily_crp_lborresu CRP Unit
daily_ldh_lborresu LDH Unit
daily_crekin_lborresu Creatine kinase Unit
daily_troponin_lborresu Troponin I Unit
daily_ddimer_lborresu D-dimer Unit
daily_ferritin_lborresu Ferritin Unit
daily_il6_lborresu IL-6 Unit
inhalednit_cmtrt Inhaled Nitric Oxide sometime?
tracheo_prtrt Tracheostomy inserted sometime?
pneumothorax_ceterm Pneumothorax
bronchio_ceterm Bronchiolitis
myocarditis_ceterm Myocarditis/Pericarditis
endocarditis_ceterm Endocarditis
cardiomyopathy_ceterm Cardiomyopathy
stroke_ceterm Stroke / Cerebrovascular accident
meningitis_ceterm Meningitis / Encephalitis
coagulo_ceterm Coagulation disorder / DIC
pulmemb_ceterm Pulmonary embolism
aneamia_ceterm Anaemia
gastro_ceterm Gastrointestinal hemorrhage
clinicalpneu_mborres Clinical pneumonia diagnosed?
xray_infiltrates_faorres Chest X-Ray performed - if YES, were infiltrates present?
antiviral_cmtrt___1 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Ribavirin)
antiviral_cmtrt___7 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Remdesivir)
corticost_cmroute___1 Corticosteroid - if YES, Route: (choice=Oral)
corticost_cmroute___2 Corticosteroid - if YES, Route: (choice=Intravenous)
heparint_cmtrt___2 Heparin - if YES: (choice=Low molecular weight)
heparint_cmtrt___3 Heparin - if YES: (choice=Fondaparinux)

Italian

Variables Description
country Country
age_estimateyearsu Age Unit
temp_vsorresu Temperature Units
weight_vsorresu Weight Unit
lymp_ceoccur_v2 Lymphadenopathy
daily_hb_lborresu Haemoglobin Unit
daily_wbc_lborresu WBC Unit
daily_lymp_lborresu Lymphocyte Unit
daily_neutro_lborresu Neutrophil Unit
daily_haematocrit_lborresu Haematocrit Unit
daily_plt_lborresu Platelets Unit
daily_alt_lborresu ALT/SGPT Unit
daily_bil_lborresu Total Bilirubin Unit
daily_ast_lborresu AST/SGOT Unit
daily_glucose_lborresu Glucose Unit
daily_bun_lborresu Urea (BUN) Unit
daily_lactate_lborresu Lactate Unit
daily_creat_lborresu Serum Creatinine Unit
daily_sodium_lborresu Sodium Unit
daily_potassium_lborresu Potassium Unit
daily_procal_lborresu Procalcitonin Unit
daily_crp_lborresu CRP Unit
daily_ldh_lborresu LDH Unit
daily_crekin_lborresu Creatine kinase Unit
daily_troponin_lborresu Troponin I Unit
daily_ddimer_lborresu D-dimer Unit
daily_ferritin_lborresu Ferritin Unit
daily_il6_lborresu IL-6 Unit
endocarditis_ceterm Endocarditis

Information Summary - One Category Variables Deleted

Calabria

Original Data Drop Factors
Number of observations 144 144
Number of variables 382 272

Humanitas

Original Data Drop Factors
Number of observations 505 505
Number of variables 251 175

Italian

Original Data Drop Factors
Number of observations 1151 1151
Number of variables 139 110

Missing Values - Patients

Next table shows if any patients have to be removed due a high number of NAs (%) considering the missing values also per variables. Those patients with a value higher than 20 % and with more NAs than the variable with more NAs will be deleted.

Calabria

Info
No observations with problems have been found

Humanitas

Patient % Missing Values
ICH-304 31
ICH-206 25
ICH-146 23
ICH-152 23
ICH-373 23
ICH-148 22
ICH-286 21

Italian

Patient % Missing Values
ICH-304 28
ICH-286 24
ICH-146 22
ICH-148 22
ICH-206 22
OMNI001-65 21

Missing Values Plots

In next section we plot the relative information for missing values for each data set.

Next plots are showing the percentage (%) of missing values per each variable. Those variables with a value higher than 20 % (red line) will be deleted. A list of the variable it’s shown in next sections. If an interesting variable is removed, could be kept.

Calabria

Variables_1/6
.

Variables_2/6
.

Variables_3/6
.

Variables_4/6
.

Variables_5/6
.

Variables_6/6
.
.

Humanitas

Variables_1/4
.

Variables_2/4
.

Variables_3/4
.

Variables_4/4
.
.

Italian

Variables_1/3
.

Variables_2/3
.

Variables_3/3
.
.

Missing Values Variables Deleted

Calabria

Variables Description
redcap_repeat_instance Repeat Instance
symptoms_epi_travel 2.A history of travel to an area with documented cases of novel coronavirus infection
symptoms_epi_physical 3.Close contact* with a confirmed or probable case of nCoV infection, while that patient was symptomatic
symptoms_epi_healthfac 4.Presence in a healthcare facility where nCoV infections have been managed
symptoms_epi_lab
  1. Presence in a laboratory handling suspected or confirmed nCoV samples
pregyn_rptestcd Pregnant?
egestage_rptestcd If YES: Gestational weeks assessment:
apvs_weight Birth weight
hosttim 2.3 Admission time at this facility
hooccur 2.4 Transfer from other facility?
siteid_transfer 2.5.1 If YES: Name of transfer facility:
hostdat_transfer 2.5.2 If YES: Admission date at transfer facility
erendat 2.6.3 If YES, return date:
rr_vsorres Respiratory rate on admission
dehydration_vsorres Severe dehydration:
height_vsorres Height on admission
weight_vsorres Weight on admission
cough_ceoccur_v2 Cough - YES/NO
coughsput_ceoccur_v2 4a.2.1 Cough: with sputum production
bleed_cetermy_v2 Bleeding (Haemorrhage) - if YES, specify site(s):
other_cetermy_v2 Other sign or symptom - if YES, specify:
pre_oralsteroid_cmtype Oral steroids - if YES, agent(s):
pre_nonoralsteroid_cmtype Other immunosuppressant agents - if YES, agent(s):
pre_antibiotic_cmtype Antibiotics - if YES, agent(s):
pre_othmed_cmtype Other targeted COVID-19 Medications - if YES, agent(s):
diabetiscomp_mhyn 4b.12. Diabetes with complications
diabetes_mhyn 4b.13. Diabetes without complications
otherrisktext Other relevant risk factor(s) - if YES, specify:
smoking_mhyn Smoking
daily_rr_vsorres Respiratory rate
daily_fio2_lborres FiO2
daily_fio2b_lborres FiO2 %
daily_fio2c_lborres FiO2 L/min
daily_sao2_lborres SaO2
daily_gcs_vsorres Glasgow Coma Score (GCS / 15):
daily_dop5to15_cmtrt Dopamine 5-15 µg/kg/min OR Epinephrine/Norepinephrine < 0.1 µg/kg/min OR Vasopressin OR Phenylephrine:
daily_dopgr15_cmtrt Dopamine > 15 µg/kg/min OR Epinephrine/Norepinephrine > 0.1 µg/kg/min:
daily_other_prtrt Other intervention(s) or procedure(s) - if YES, specify:
rass_vsorres Richmond Agitation-Sedation Scale (RASS)
daily_meanart_vsorres Mean Arterial Pressure:
daily_urine_lborres Urine flow rate:
daily_aptt_lborres APTT/APTR
daily_aptr_lborres APTR
daily_pt_inr_lbyn PT or INR available?
daily_inr_lborres INR
daily_glucose_lborres Glucose
daily_procal_lborres Procalcitonin
daily_ldh_lborres LDH
daily_crekin_lborres Creatine kinase
daily_troponin_lborres Troponin I
daily_ddimer_lborres D-dimer
daily_ferritin_lborres Ferritin
daily_il6_lborres IL-6
infiltrates_faorres If yes, were infiltrates present?
noninvaisve_prdur Non-invasive ventilation - if YES, total duration:
invasive_prdur Invasive ventilation - if YES, total duration:
prone_prdur Prone positioning sometime - if YES, total duration:
inotrop_prdur Inotropes/vasopressors - if YES, total duration:
inotrope_cmstdat If YES inotropes/vasopressors; First/Start Date
inotrope_cmendat If YES inotropes/vasopressors; Last/End date
ardssev_ceterm Acute Respiratory Distress Syndrome - if YES, specify:
other_ceterm Other - if YES, specify:
bact_mborres Bacteria
bact_mbtest Bacteria - if Positive, specify:
other_mborres Other pathogen(s) detected - if YES, specify all:
ct_infiltrates_faorres CT performed - if YES, were infiltrates present?
mbdat Collection Date
other_mbspec Biospecimen type - if Other, specify:
other_mbmethod Laboratory test method - if Other, specify:
mbtestcd Pathogen Tested / Detected
lopin_antiviral_cmdat Lopinavir/Ritonvir - Date commenced
lopin_antiviral_cmdur Lopinavir/Ritonvir - Duration:
remde_antiviral_cmdat Remdesivir - Date commenced
remde_antiviral_cmdur Remdesivir - Duration:
chlor_antiviral_cmdat Chloroquine/hydroxychloroquine - Date commenced
chlor_antiviral_cmdur Chloroquine/hydroxychloroquine - Duration:
antiviral_cmtype Other agent - if YES, agent name:
antiviral_cmdat Other agent - Date commenced
antiviral_cmdur Other agent - Duration:
antibiotic_cmtrt_1 Antibiotic Agent 1 - if YES, agent name:
antibiotic_cmdat_1 Antibiotic Agent 1 - Date commenced
antibiotic_cmdur_1 Antibiotic Agent 1 - Duration:
antibiotic_cmtrt_2 Antibiotic Agent 2 - if YES, agent name:
antibiotic_cmdat_2 Antibiotic Agent 2 - Date commenced
antibiotic_cmdur_2 Antibiotic Agent 2 - Duration:
antibiotic_cmtrt_3 Antibiotic Agent 3 - if YES, agent name:
antibiotic_cmdat_3 Antibiotic Agent 3 - Date commenced
antibiotic_cmdur_3 Antibiotic Agent 3 - Duration:
corticost_cmtrt Corticosteroid - if YES Oral or IV, please provide agent:
corticost_cmdose Corticosteroid - if YES Oral or IV, please provide max. daily dose and unit:
corticos_cmdat Corticosteroid - Date commenced
corticos_cmdur Corticosteroid - Duration:
heparint_cmdose Heparin - Maximum daily dose and unit:
heparin_cmdat Heparin - Date commenced
heparin_cmdur Heparin - Duration:
othertx_cmtrt_1 Other Agent 1 - Agent:
othertx_cmdos_1 Other Agent 1 - Maximum daily dose & unit:
othertx_cmdat_1 Other Agent 1 - Date of commencement
othertx_cmdur_1 Other Agent 1 - Duration:
othertx_cmtrt_2 Other Agent 2 - Agent:
othertx_cmdos_2 Other Agent 2 - Maximum daily dose & unit:
othertx_cmdat_2 Other Agent 2 - Date of commencement
othertx_cmdur_2 Other Agent 2 - Duration:
suppds_qval Ability to self-care at discharge versus before illness:
oxygen_proccur Post discharge treatment: Oxygen therapy?
core_addinfo Additional Information
PaO2overFiO2 P/F (PaO2/FiO2)

Humanitas

Variables Description
oxy_vsorres Oxygen saturation on admission
oxy_vsorresu Oxygen saturation on:
weight_vsorres Weight on admission
pre_oralsteroid_cmtype Oral steroids - if YES, agent(s):
pre_antibiotic_cmtype Antibiotics - if YES, agent(s):
daily_fi02_lbyn Any supplemental oxygen: FiO2
daily_fio2_lborres FiO2
daily_fio2b_lborres FiO2 %
daily_noninvasive_prtype Non-invasive ventilation - if YES:
daily_pao2_lborres PaO2 (at time nearest to the FiO2 recorded at top of page):
daily_pco2_lborres PCO2
daily_ph_lborres pH
daily_hco3_lborres HCO3-
daily_baseex_lborres Base excess
daily_hb_lborres Haemoglobin
daily_glucose_lborres Glucose
daily_lactate_lborres Lactate
daily_procal_lborres Procalcitonin
daily_ldh_lborres LDH
daily_troponin_lborres Troponin I
daily_ddimer_lborres D-dimer
daily_ferritin_lborres Ferritin
daily_il6_lborres IL-6
oxygen_cmdose Maximum O2 flow volume:
noninvaisve_prdur Non-invasive ventilation - if YES, total duration:
invasive_prdur Invasive ventilation - if YES, total duration:
inotrope_cmstdat If YES inotropes/vasopressors; First/Start Date
inotrope_cmendat If YES inotropes/vasopressors; Last/End date
other_ceterm Other - if YES, specify:
antiviral_cmyn Antiviral or COVID-19 targeted agent?
antiviral_cmtrt___2 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Lopinavir/Ritonvir)
lopin_antiviral_cmdat Lopinavir/Ritonvir - Date commenced
lopin_antiviral_cmdur Lopinavir/Ritonvir - Duration:
chlor_antiviral_cmdat Chloroquine/hydroxychloroquine - Date commenced
chlor_antiviral_cmdur Chloroquine/hydroxychloroquine - Duration:
antiviral_cmtype Other agent - if YES, agent name:
antiviral_cmdat Other agent - Date commenced
antiviral_cmdur Other agent - Duration:
antibiotic_cmyn Antibiotic?
antibiotic_cmtrt_1 Antibiotic Agent 1 - if YES, agent name:
antibiotic_cmdat_1 Antibiotic Agent 1 - Date commenced
antibiotic_cmdur_1 Antibiotic Agent 1 - Duration:
antibiotic_cmtrt_2 Antibiotic Agent 2 - if YES, agent name:
antibiotic_cmdat_2 Antibiotic Agent 2 - Date commenced
antibiotic_cmdur_2 Antibiotic Agent 2 - Duration:
antibiotic_cmtrt_3 Antibiotic Agent 3 - if YES, agent name:
antibiotic_cmdat_3 Antibiotic Agent 3 - Date commenced
antibiotic_cmdur_3 Antibiotic Agent 3 - Duration:
corticost_cmyn Corticosteroid?
corticost_cmtrt Corticosteroid - if YES Oral or IV, please provide agent:
corticost_cmdose Corticosteroid - if YES Oral or IV, please provide max. daily dose and unit:
corticos_cmdat Corticosteroid - Date commenced
corticos_cmdur Corticosteroid - Duration:
heparint_cmyn Heparin?
heparint_cmdose Heparin - Maximum daily dose and unit:
heparin_cmdat Heparin - Date commenced
heparin_cmdur Heparin - Duration:
suppds_qval Ability to self-care at discharge versus before illness:
oxygen_proccur Post discharge treatment: Oxygen therapy?
siteid 7.4.1. If Transferred: Facility name
PaO2overFiO2 P/F (PaO2/FiO2)

Italian

Variables Description
rr_vsorres Respiratory rate on admission
oxy_vsorres Oxygen saturation on admission
oxy_vsorresu Oxygen saturation on:
weight_vsorres Weight on admission
chroniccard_mhyn Chronic cardiac disease (not hypertension)
smoking_mhyn Smoking
daily_hb_lborres Haemoglobin
daily_alt_lborres ALT/SGPT
daily_bil_lborres Total Bilirubin
daily_ast_lborres AST/SGOT
daily_glucose_lborres Glucose
daily_bun_lborres Urea (BUN)
daily_lactate_lborres Lactate
daily_procal_lborres Procalcitonin
daily_ldh_lborres LDH
daily_crekin_lborres Creatine kinase
daily_troponin_lborres Troponin I
daily_ddimer_lborres D-dimer
daily_ferritin_lborres Ferritin
daily_il6_lborres IL-6

Information Summary - Missing Values

Calabria

Original Data Drop Factors NA Filter
Number of observations 144 144 144
Number of variables 382 272 165

Humanitas

Original Data Drop Factors NA Filter
Number of observations 505 505 498
Number of variables 251 175 114

Italian

Original Data Drop Factors NA Filter
Number of observations 1151 1151 1145
Number of variables 139 110 90

Qualitative Analysis

First, deletion for Near Zero Variance Variables. As they are qualitative variables, the deletion takes into account the number of categories and the frequency of each one. Function we used was provided for “caret” R package (http://rismyhammer.com/ml/Pre-Processing.html#zero-and-near-zero-variance-predictors).

Calabria

Variables Description
ethnic___1 Ethnic group (choice=Arab)
ethnic___2 Ethnic group (choice=Black)
ethnic___3 Ethnic group (choice=East Asian)
ethnic___4 Ethnic group (choice=South Asian)
ethnic___6 Ethnic group (choice=Latin American)
healthwork_erterm Employed as a healthcare worker?
sorethroat_ceoccur_v2 Sore throat
runnynose_ceoccur_v2 Runny nose (Rhinorrhoea)
wheeze_ceoccur_v2 Wheezing
headache_ceoccur_v2 Headache
anosmia_ceoccur_v2 Loss of smell (Anosmia)
seizures_cecoccur_v2 Seizures
abdopain_ceoccur_v2 Abdominal pain
vomit_ceoccur_v2 Vomiting / Nausea
rash_ceoccur_v2 Skin rash
bleed_ceoccur_v2 Bleeding (Haemorrhage)
other_ceoccur_v2 Other sign or symptom
pre_oralsteroid_cmoccur Oral steroids
pre_nonoralsteroid_cmoccur Other immunosuppressant agents (not oral steroids)
pre_othmed_cmoccur Other targeted COVID-19 Medications
asthma_mhyn Asthma (physician diagnosed)
modliver_mhyn Moderate or severe liver disease
mildliv_mhyn Mild liver disease
asplenia_mhyn Asplenia
chronhaemo_mhyn Chronic hematologic disease
tb_mhyn Tuberculosis
malnutrition_mhyn Malnutrition
daily_noninvasive_prtrt Non-invasive ventilation (Any)?
daily_invasive_prtrt Invasive ventilation?
daily_prone_cmtrt Prone Positioning?
daily_inotrope_cmyn Any vasopressor / inotropic support?
daily_neuro_cmtrt Neuromuscular blocking agents?
daily_hoterm Current admission to ICU/ITU/IMC/HDU?
daily_meanart_lbyn Mean Arterial Pressure available?
tracheo_prtrt Tracheostomy inserted sometime?
pneumothorax_ceterm Pneumothorax
cardiomyopathy_ceterm Cardiomyopathy
bacteraemia_ceterm Bacteraemia
coagulo_ceterm Coagulation disorder / DIC
pulmemb_ceterm Pulmonary embolism
rhabdomyolsis_ceterm Rhabdomyolysis / Myositis
gastro_ceterm Gastrointestinal hemorrhage
hypoglycemia_ceterm Hypoglycaemia
xray_prperf_v2 Chest X-Ray performed?
antiviral_cmtrt___7 Antiviral or COVID-19 targeted agent - if YES, specify all agents: (choice=Remdesivir)
corticost_cmroute___1 Corticosteroid - if YES, Route: (choice=Oral)
corticost_cmroute___3 Corticosteroid - if YES, Route: (choice=Inhaled)
heparint_cmtrt___1 Heparin - if YES: (choice=Unfractionated)
heparint_cmtrt___3 Heparin - if YES: (choice=Fondaparinux)
heparint_cmtrt___4 Heparin - if YES: (choice=Unknown)
antifung_cmyn Antifungal agent?

Humanitas

Variables Description
ethnic___6 Ethnic group (choice=Latin American)
ethnic___7 Ethnic group (choice=White)
healthwork_erterm Employed as a healthcare worker?
hoyn Was the patient admitted previously or transferred from any other facility during this illness episode?
sorethroat_ceoccur_v2 Sore throat
runnynose_ceoccur_v2 Runny nose (Rhinorrhoea)
wheeze_ceoccur_v2 Wheezing
lowerchest_ceoccur_v2 Lower chest wall indrawing
headache_ceoccur_v2 Headache
anosmia_ceoccur_v2 Loss of smell (Anosmia)
ageusia_ceoccur_v2 Loss of taste (Ageusia)
fatigue_ceoccur_v2 Fatigue / Malaise
confusion_ceoccur_v2 Altered consciousness / confusion
abdopain_ceoccur_v2 Abdominal pain
bleed_ceoccur_v2 Bleeding (Haemorrhage)
pre_ace_cmoccur Angiotensin converting enzyme inhibitors (ACE inhibitors)
pre_arb_cmoccur Angiotensin II receptor blockers (ARBs)
pre_oralsteroid_cmoccur Oral steroids
pre_antiviral_cmoccur Antivirals
pre_antibiotic_cmoccur Antibiotics
asthma_mhyn Asthma (physician diagnosed)
obesity_mhyn Obesity (as defined by clinical staff)
modliver_mhyn Moderate or severe liver disease
mildliv_mhyn Mild liver disease
chronicneu_mhyn Chronic neurological disorder
chronhaemo_mhyn Chronic hematologic disease
rheumatology_mhyr Rheumatologic disorder
dementia_mhyn Dementia
daily_nasaloxy_cmtrt High-flow nasal canula oxygen therapy?
daily_prone_cmtrt Prone Positioning?
daily_inotrope_cmyn Any vasopressor / inotropic support?
daily_neuro_cmtrt Neuromuscular blocking agents?
inotrop_cmtrt Inotropes / vasopressors?
viralpneu_ceterm Viral pneumonia/pneumonitis
ards_ceterm Acute Respiratory Distress Syndrome
pleuraleff_ceterm Pleural effusion
cardiacarrest_ceterm Cardiac arrest
myocardial_ceterm Myocardial infarction
ischaemia_ceterm Cardiac ischemia
arrhythmia_ceterm Cardiac arrhythmia
heartfailure_ceterm Congestive heart failure
seizure_ceterm Seizure
liverdysfunction_ceterm Liver dysfunction
xray_prperf_v2 Chest X-Ray performed?
ct_prperf CT performed?
ct_infiltrates_faorres CT performed - if YES, were infiltrates present?

Italian

Variables Description
ethnic___1 Ethnic group (choice=Arab)
ethnic___2 Ethnic group (choice=Black)
ethnic___3 Ethnic group (choice=East Asian)
ethnic___4 Ethnic group (choice=South Asian)
ethnic___5 Ethnic group (choice=West Asian)
ethnic___6 Ethnic group (choice=Latin American)
ethnic___7 Ethnic group (choice=White)
ethnic___8 Ethnic group (choice=Aboriginal/First Nations)
ethnic___9 Ethnic group (choice=Other)
healthwork_erterm Employed as a healthcare worker?
sorethroat_ceoccur_v2 Sore throat
runnynose_ceoccur_v2 Runny nose (Rhinorrhoea)
lowerchest_ceoccur_v2 Lower chest wall indrawing
chestpain_ceoccur_v2 Chest pain
conjunct_ceoccur_v2 Conjunctivitis
headache_ceoccur_v2 Headache
anosmia_ceoccur_v2 Loss of smell (Anosmia)
ageusia_ceoccur_v2 Loss of taste (Ageusia)
seizures_cecoccur_v2 Seizures
confusion_ceoccur_v2 Altered consciousness / confusion
jointpain_ceoccur_v2 Joint pain (Arthralgia)
abdopain_ceoccur_v2 Abdominal pain
rash_ceoccur_v2 Skin rash
asthma_mhyn Asthma (physician diagnosed)
modliver_mhyn Moderate or severe liver disease
mildliv_mhyn Mild liver disease
chronhaemo_mhyn Chronic hematologic disease
rheumatology_mhyr Rheumatologic disorder
dementia_mhyn Dementia
malnutrition_mhyn Malnutrition
tracheo_prtrt Tracheostomy inserted sometime?
ischaemia_ceterm Cardiac ischemia
arrhythmia_ceterm Cardiac arrhythmia
myocarditis_ceterm Myocarditis/Pericarditis
heartfailure_ceterm Congestive heart failure
seizure_ceterm Seizure
stroke_ceterm Stroke / Cerebrovascular accident
pulmemb_ceterm Pulmonary embolism

Information Summary - NZV Removed

Calabria

Original Data Drop Factors NA Filter QUAL - NZV Filter
Number of observations 144 144 144 144
Number of variables 382 272 165 114

Humanitas

Original Data Drop Factors NA Filter QUAL - NZV Filter
Number of observations 505 505 498 498
Number of variables 251 175 114 68

Italian

Original Data Drop Factors NA Filter QUAL - NZV Filter
Number of observations 1151 1151 1145 1145
Number of variables 139 110 90 52

Qualitative Analysis - Plots

Qualitative variables for merged data sets are shown. A chi2 test is perform for each variable in merge databases.

Calabria

ethnic___7
.

hoyn
.

oxy_vsorresu
.

fever_ceoccur_v2
.

cough_ceoccur_v2_2
.

shortbreath_ceoccur_v2
.

chestpain_ceoccur_v2
.

fatigue_ceoccur_v2
.

anorexia_ceoccur_v2
.

confusion_ceoccur_v2
.

myalgia_ceoccur_v2
.

jointpain_ceoccur_v2
.

inablewalk_ceoccur_v2
.

diarrhoea_ceoccur_v2
.

pre_ace_cmoccur
.

pre_arb_cmoccur
.

pre_nsaid_cmoccur
.

pre_antibiotic_cmoccur
.

chroniccard_mhyn
.

hypertension_mhyn
.

chronicpul_mhyn
.

renal_mhyn
.

obesity_mhyn
.

chronicneu_mhyn
.

malignantneo_mhyn
.

diabetes_mhyn_2
.

rheumatology_mhyr
.

dementia_mhyn
.

other_mhyn
.

daily_fi02_lbyn
.

avpu_vsorres
.

daily_gcs_lbyn
.

daily_nasaloxy_cmtrt
.

oxygen_cmoccur
.

oxygen_cmdose
.

noninvasive_proccur
.

invasive_proccur
.

pronevent_prtrt
.

inotrop_cmtrt
.

icu_hoterm
.

viralpneu_ceterm
.

bactpneu_ceterm
.

ards_ceterm
.

pleuraleff_ceterm
.

arrhythmia_ceterm
.

heartfailure_ceterm
.

aneamia_ceterm
.

renalinjury_ceterm
.

liverdysfunction_ceterm
.

hyperglycemia_aeterm
.

other_ceoccur
.

other_mbyn
.

clinicalpneu_mborres
.

xray_infiltrates_faorres
.

ct_prperf
.

antiviral_cmyn
.

antiviral_cmtrt___2
.

antiviral_cmtrt___8
.

antiviral_cmtrt___6
.

antibiotic_cmyn
.

corticost_cmyn
.

corticost_cmroute___2
.

heparint_cmyn
.

heparint_cmroute___1
.

heparint_cmtrt___2
.

othertx_cmyn
.

age_estimateyears.qual
.
.

Humanitas

fever_ceoccur_v2
.

cough_ceoccur_v2_2
.

cough_ceoccur_v2
.

shortbreath_ceoccur_v2
.

chestpain_ceoccur_v2
.

myalgia_ceoccur_v2
.

jointpain_ceoccur_v2
.

diarrhoea_ceoccur_v2
.

vomit_ceoccur_v2
.

chroniccard_mhyn
.

hypertension_mhyn
.

chronicpul_mhyn
.

renal_mhyn
.

malignantneo_mhyn
.

diabetes_mhyn_2
.

smoking_mhyn
.

daily_noninvasive_prtrt
.

daily_invasive_prtrt
.

daily_hoterm
.

oxygen_cmoccur
.

noninvasive_proccur
.

invasive_proccur
.

pronevent_prtrt
.

icu_hoterm
.

bactpneu_ceterm
.

age_estimateyears.qual
.
.

Italian

hoyn
.

fever_ceoccur_v2
.

shortbreath_ceoccur_v2
.

fatigue_ceoccur_v2
.

myalgia_ceoccur_v2
.

diarrhoea_ceoccur_v2
.

vomit_ceoccur_v2
.

hypertension_mhyn
.

chronicpul_mhyn
.

renal_mhyn
.

obesity_mhyn
.

chronicneu_mhyn
.

malignantneo_mhyn
.

diabetes_mhyn_2
.

oxygen_cmoccur
.

noninvasive_proccur
.

pronevent_prtrt
.

icu_hoterm
.

viralpneu_ceterm
.

ards_ceterm
.

xray_prperf_v2
.

ct_prperf
.

age_estimateyears.qual
.
.

Quantitative Analysis

A Coefficient CutOff is applied to remove near-zero variance variables.

Calabria

Info
No observations with problems have been found

Humanitas

Info
No observations with problems have been found

Italian

Info
No observations with problems have been found

Information Summary - NZV Removed - Quantitative

Calabria

Original Data Drop Factors NA Filter QUAL - NZV Filter NUM - NZV Filter
Number of observations 144 144 144 144 144
Number of variables 382 272 165 114 114

Humanitas

Original Data Drop Factors NA Filter QUAL - NZV Filter NUM - NZV Filter
Number of observations 505 505 498 498 498
Number of variables 251 175 114 68 68

Italian

Original Data Drop Factors NA Filter QUAL - NZV Filter NUM - NZV Filter
Number of observations 1151 1151 1145 1145 1145
Number of variables 139 110 90 52 52

Quantitative Analysis - Plots

Stack histogram and violin/boxplot is shown for each numerical variable in merged data sets. Possible outliers are detected by using the \(Q3+1.5*IQR\) and \(Q1+1.5*IQR\) formula for the entire range of values (not by hospital).

Calabria

age_estimateyears
.

temp_vsorres
.

hr_vsorres
.

sysbp_vsorres
.

admission_diabp_vsorres
.

oxy_vsorres
.

daily_temp_vsorres
.

daily_hr_vsorres
.

systolic_vsorres
.

diastolic_vsorres
.

daily_oxy_vsorres
.

daily_pao2_lborres
.

daily_pco2_lborres
.

daily_ph_lborres
.

daily_hco3_lborres
.

daily_baseex_lborres
.

daily_hb_lborres
.

daily_wbc_lborres
.

daily_lymp_lborres
.

daily_neutro_lborres
.

daily_haematocrit_lborres
.

daily_plt_lborres
.

daily_alt_lborres
.

daily_bil_lborres
.

daily_ast_lborres
.

daily_bun_lborres
.

daily_lactate_lborres
.

daily_creat_lborres
.

daily_sodium_lborres
.

daily_potassium_lborres
.

daily_crp_lborres
.

oxygen_cmdur
.

SymptomsDays
.

comorbidities
.

GlobalSurvival
.

hodur
.
.

Humanitas

age_estimateyears
.

temp_vsorres
.

hr_vsorres
.

rr_vsorres
.

sysbp_vsorres
.

admission_diabp_vsorres
.

daily_temp_vsorres
.

daily_hr_vsorres
.

daily_rr_vsorres
.

systolic_vsorres
.

diastolic_vsorres
.

daily_oxy_vsorres
.

daily_wbc_lborres
.

daily_lymp_lborres
.

daily_neutro_lborres
.

daily_haematocrit_lborres
.

daily_plt_lborres
.

daily_inr_lborres
.

daily_alt_lborres
.

daily_bil_lborres
.

daily_ast_lborres
.

daily_bun_lborres
.

daily_creat_lborres
.

daily_sodium_lborres
.

daily_potassium_lborres
.

daily_crp_lborres
.

daily_crekin_lborres
.

SymptomsDays
.

comorbidities
.

GlobalSurvival
.

hodur
.
.

Italian

age_estimateyears
.

temp_vsorres
.

hr_vsorres
.

sysbp_vsorres
.

admission_diabp_vsorres
.

daily_wbc_lborres
.

daily_lymp_lborres
.

daily_neutro_lborres
.

daily_haematocrit_lborres
.

daily_plt_lborres
.

daily_creat_lborres
.

daily_sodium_lborres
.

daily_potassium_lborres
.

daily_crp_lborres
.

SymptomsDays
.

comorbidities
.

GlobalSurvival
.

hodur
.
.

Quantitative Analysis - Outliers

Calabria

age_estimateyears

Info
No observations with problems have been found

temp_vsorres

Patients Values
481-0022 40.5
481-0191 40.4

hr_vsorres

Patients Values
1 481-0003 170
3 481-0082 140
2 481-0081 137
4 481-0126 40
5 481-0171 40

sysbp_vsorres

Patients Values
481-0075 210
481-0080 210

admission_diabp_vsorres

Patients Values
481-0145 105

oxy_vsorres

Patients Values
4 481-0052 85
11 481-0159 84
12 481-0194 84
6 481-0066 83
2 481-0030 82
3 481-0041 82
1 481-0012 80
5 481-0064 80
7 481-0079 80
9 481-0136 76
8 481-0126 74
10 481-0149 71

daily_temp_vsorres

Info
No observations with problems have been found

daily_hr_vsorres

Patients Values
481-0171 45

systolic_vsorres

Patients Values
481-0080 210

diastolic_vsorres

Patients Values
1 481-0041 100
2 481-0077 100
3 481-0078 100
6 481-0157 100
5 481-0149 50
4 481-0082 40

daily_oxy_vsorres

Patients Values
8 481-0128 88
2 481-0036 87
3 481-0052 85
5 481-0073 84
10 481-0194 84
1 481-0003 83
4 481-0066 83
9 481-0136 76
7 481-0126 74
6 481-0079 49

daily_pao2_lborres

Patients Values
6 481-0082 155
1 481-0027 151
2 481-0035 130
3 481-0048 116
4 481-0055 115
5 481-0065 112
7 481-0113 109

daily_pco2_lborres

Patients Values
2 481-0041 66
4 481-0065 60
1 481-0027 59
5 481-0126 59
3 481-0055 51

daily_ph_lborres

Patients Values
481-0003 7.31
481-0041 7.3
481-0126 7.14

daily_hco3_lborres

Patients Values
2 481-0134 37
1 481-0019 36.8

daily_baseex_lborres

Patients Values
5 481-0134 17.7
1 481-0019 14.1
3 481-0065 13.1
2 481-0023 12.7
4 481-0087 -13

daily_hb_lborres

Patients Values
2 481-0141 86
1 481-0068 84
3 481-0197 84

daily_wbc_lborres

Patients Values
2 481-0029 16.4
3 481-0096 14.9
1 481-0027 14.2

daily_lymp_lborres

Patients Values
1 481-0027 8
6 481-0194 5.3
7 481-0196 3.83
2 481-0043 2.8
5 481-0181 2.8
4 481-0153 2.62
3 481-0074 2.4

daily_neutro_lborres

Patients Values
1 481-0029 14.5
3 481-0096 13.1
2 481-0040 11.9

daily_haematocrit_lborres

Info
No observations with problems have been found

daily_plt_lborres

Patients Values
4 481-0150 570
1 481-0055 446
2 481-0088 444
3 481-0119 421

daily_alt_lborres

Patients Values
3 481-0041 761
8 481-0118 201
1 481-0003 146
9 481-0136 132
2 481-0004 128
10 481-0145 120
6 481-0066 118
7 481-0081 115
4 481-0044 107
5 481-0064 99
11 481-0163 96

daily_bil_lborres

Patients Values
5 481-0168 77.7
3 481-0082 50
1 481-0004 30.9
2 481-0061 27.8
4 481-0120 26.3

daily_ast_lborres

Patients Values
6 481-0041 1549
1 481-0003 243
10 481-0118 220
2 481-0004 210
13 481-0168 197
4 481-0013 157
5 481-0032 155
8 481-0064 129
7 481-0044 126
3 481-0012 118
9 481-0099 116
12 481-0149 116
11 481-0127 109

daily_bun_lborres

Patients Values
5 481-0087 40.16
8 481-0149 38.47
6 481-0096 24.34
9 481-0171 24.3
2 481-0035 22.44
4 481-0085 22.08
3 481-0079 21.11
1 481-0003 20.9
7 481-0130 18.7

daily_lactate_lborres

Patients Values
3 481-0085 5.6
4 481-0096 3.7
5 481-0126 3.7
1 481-0079 3.6
8 481-0175 2.8
2 481-0081 2.6
6 481-0168 2.5
7 481-0174 2.5

daily_creat_lborres

Patients Values
6 481-0149 385
1 481-0003 320
2 481-0035 249
4 481-0085 221
3 481-0068 220
5 481-0115 212

daily_sodium_lborres

Patients Values
3 481-0106 163
5 481-0149 163
2 481-0096 155
4 481-0126 155
1 481-0082 153
6 481-0150 118

daily_potassium_lborres

Patients Values
3 481-0079 5.77
2 481-0035 5.46
4 481-0085 5.14
1 481-0013 5.07
5 481-0107 2.53

daily_crp_lborres

Info
No observations with problems have been found

oxygen_cmdur

Patients Values
2 481-0157 43
1 481-0134 39

SymptomsDays

Patients Values
481-0074 29

comorbidities

Patients Values
2 481-0028 2
1 481-0003 1.5

GlobalSurvival

Info
No observations with problems have been found

hodur

Info
No observations with problems have been found

Humanitas

age_estimateyears

Info
No observations with problems have been found

temp_vsorres

Patients Values
2 ICH-28 39
3 ICH-587 38.54
1 ICH-186 38.53

hr_vsorres

Patients Values
6 ICH-523 132.2
8 ICH-639 123.2
5 ICH-517 120.2
3 ICH-270 117.5
7 ICH-555 114.2
4 ICH-429 114
1 ICH-157 113.9
2 ICH-193 112.2

rr_vsorres

Patients Values
3 ICH-157 31.67
23 ICH-600 31
15 ICH-463 29.2
20 ICH-52 26.5
9 ICH-263 25
4 ICH-173 24.33
18 ICH-517 24
22 ICH-573 24
8 ICH-237 23.67
14 ICH-434 23.6
19 ICH-519 23.5
11 ICH-359 23.33
7 ICH-208 22.5
13 ICH-417 22.5
25 ICH-90 22.5
5 ICH-181 22.33
1 ICH-118 22.25
12 ICH-402 22.25
2 ICH-147 22
6 ICH-198 22
10 ICH-347 22
16 ICH-471 22
17 ICH-477 22
24 ICH-83 22
21 ICH-569 14.67

sysbp_vsorres

Patients Values
3 ICH-443 175
5 ICH-542 175
9 ICH-600 165.9
1 ICH-14 161.7
4 ICH-502 161.5
6 ICH-590 160.7
7 ICH-598 160.5
8 ICH-60 160.2
2 ICH-27 78.33

admission_diabp_vsorres

Patients Values
2 ICH-221 93.33
4 ICH-568 48.33
5 ICH-610 48.29
3 ICH-357 47
1 ICH-173 40.12

daily_temp_vsorres

Patients Values
2 ICH-28 39
3 ICH-587 38.54
1 ICH-186 38.53

daily_hr_vsorres

Patients Values
7 ICH-523 132.2
9 ICH-639 123.2
6 ICH-517 120.2
4 ICH-270 117.5
8 ICH-555 114.2
5 ICH-429 114
1 ICH-157 113.9
2 ICH-193 112.2
3 ICH-211 52.25

daily_rr_vsorres

Patients Values
3 ICH-157 31.67
25 ICH-600 31
17 ICH-463 29.2
22 ICH-52 26.5
11 ICH-263 25
4 ICH-173 24.33
20 ICH-517 24
24 ICH-573 24
9 ICH-237 23.67
16 ICH-434 23.6
21 ICH-519 23.5
13 ICH-359 23.33
8 ICH-208 22.5
15 ICH-417 22.5
27 ICH-90 22.5
5 ICH-181 22.33
1 ICH-118 22.25
14 ICH-402 22.25
2 ICH-147 22
7 ICH-198 22
12 ICH-347 22
18 ICH-471 22
19 ICH-477 22
26 ICH-83 22
6 ICH-182 15
10 ICH-253 15
23 ICH-569 14.67

systolic_vsorres

Patients Values
4 ICH-443 175
7 ICH-542 175
11 ICH-600 165.9
2 ICH-229 165
1 ICH-14 161.7
5 ICH-502 161.5
8 ICH-590 160.7
9 ICH-598 160.5
10 ICH-60 160.2
6 ICH-52 89
3 ICH-27 78.33

diastolic_vsorres

Patients Values
2 ICH-221 93.33
4 ICH-568 48.33
3 ICH-357 47
1 ICH-173 40.12

daily_oxy_vsorres

Patients Values
12 ICH-220 89
20 ICH-353 89
30 ICH-598 88.86
11 ICH-215 88
17 ICH-299 88
22 ICH-400 88
29 ICH-517 88
21 ICH-367 87.4
26 ICH-480 87
27 ICH-486 87
32 ICH-67 87
34 ICH-76 86.75
1 ICH-100 86
3 ICH-12 86
7 ICH-162 86
33 ICH-69 85
6 ICH-157 84.17
2 ICH-104 84
16 ICH-267 83
5 ICH-150 82
8 ICH-173 82
25 ICH-463 82
35 ICH-8 82
4 ICH-120 80
9 ICH-192 80
10 ICH-204 79
14 ICH-264 79
13 ICH-242 77
19 ICH-352 77
31 ICH-664 75
15 ICH-265 74
18 ICH-314 70
24 ICH-446 66
28 ICH-505 60
36 ICH-92 43
23 ICH-426 40

daily_wbc_lborres

Patients Values
30 ICH-639 113.2
27 ICH-600 38.17
3 ICH-161 29.54
10 ICH-314 26.32
19 ICH-480 23.49
13 ICH-405 21.5
6 ICH-229 20.5
22 ICH-52 20.19
7 ICH-233 20.07
23 ICH-523 19.85
14 ICH-416 19.56
17 ICH-465 19.46
12 ICH-34 19.12
29 ICH-629 19.04
4 ICH-163 18.59
5 ICH-164 18.22
8 ICH-246 17.49
21 ICH-505 17.14
15 ICH-435 17.12
1 ICH-147 16.87
2 ICH-160 15.84
16 ICH-447 15.82
28 ICH-616 15.78
24 ICH-538 15.73
18 ICH-48 15.71
26 ICH-598 15.62
20 ICH-500 15.37
32 ICH-79 15.28
25 ICH-544 14.46
11 ICH-316 14.42
9 ICH-282 14.38
31 ICH-78 14.35

daily_lymp_lborres

Patients Values
3 ICH-161 12.3
4 ICH-233 9.5
7 ICH-316 7.7
8 ICH-361 4.4
2 ICH-147 4.35
14 ICH-92 3.8
12 ICH-648 3.6
11 ICH-539 3.3
10 ICH-503 2.8
1 ICH-126 2.7
5 ICH-275 2.7
13 ICH-66 2.7
6 ICH-314 2.65
9 ICH-481 2.6

daily_neutro_lborres

Patients Values
23 ICH-600 35
9 ICH-314 21.25
16 ICH-480 21
18 ICH-52 19.1
6 ICH-229 18.95
11 ICH-405 18.7
14 ICH-465 18.3
19 ICH-523 18
1 ICH-16 17.95
12 ICH-416 17.7
25 ICH-629 17.1
7 ICH-246 16.2
3 ICH-161 16.1
4 ICH-163 16
10 ICH-34 15.65
5 ICH-164 15.4
17 ICH-505 15.25
13 ICH-435 14.95
22 ICH-598 14.9
20 ICH-538 14.3
15 ICH-48 13.9
2 ICH-160 13.7
21 ICH-544 13.6
26 ICH-79 13.3
8 ICH-282 13.05
24 ICH-616 12.9

daily_haematocrit_lborres

Patients Values
10 ICH-515 53.4
12 ICH-642 50.2
8 ICH-357 25.8
4 ICH-204 25.7
14 ICH-79 25
11 ICH-639 24.9
9 ICH-397 24.8
1 ICH-139 24.5
6 ICH-233 24.5
5 ICH-232 24.4
2 ICH-171 24
7 ICH-317 23.7
3 ICH-173 22.95
13 ICH-660 22.6

daily_plt_lborres

Patients Values
1 ICH-163 917
8 ICH-556 663
2 ICH-181 623
7 ICH-539 581
5 ICH-398 542
6 ICH-503 524
4 ICH-229 520
12 ICH-92 492
11 ICH-73 484
9 ICH-557 480
3 ICH-219 466
10 ICH-559 462

daily_inr_lborres

Patients Values
20 ICH-351 8.72
3 ICH-139 7.46
15 ICH-247 3.85
16 ICH-263 3.76
9 ICH-22 3.63
19 ICH-347 2.3
18 ICH-343 2.26
28 ICH-559 2.09
29 ICH-595 2.06
12 ICH-241 1.93
6 ICH-173 1.915
1 ICH-120 1.84
22 ICH-367 1.75
4 ICH-153 1.71
10 ICH-225 1.69
14 ICH-246 1.68
8 ICH-219 1.66
25 ICH-45 1.63
23 ICH-40 1.6
30 ICH-629 1.59
31 ICH-653 1.59
5 ICH-160 1.58
17 ICH-313 1.57
7 ICH-197 1.56
24 ICH-440 1.56
26 ICH-47 1.56
13 ICH-244 1.55
27 ICH-509 1.54
11 ICH-229 1.535
2 ICH-129 1.53
21 ICH-362 1.52

daily_alt_lborres

Patients Values
8 ICH-242 347
15 ICH-435 256
17 ICH-45 256
3 ICH-145 217.5
27 ICH-629 190
29 ICH-673 187
18 ICH-450 183
28 ICH-632 175
1 ICH-114 174
24 ICH-550 162
21 ICH-511 156
4 ICH-155 152
12 ICH-383 145
6 ICH-184 137
30 ICH-68 129
13 ICH-398 120
16 ICH-449 115
19 ICH-490 112
11 ICH-332 111
26 ICH-578 109.5
23 ICH-529 109
31 ICH-9 109
2 ICH-121 108
14 ICH-400 108
7 ICH-2 101
5 ICH-183 99
10 ICH-307 99
22 ICH-526 94
25 ICH-553 93
20 ICH-493 92
9 ICH-270 91

daily_bil_lborres

Patients Values
5 ICH-242 254.8
19 ICH-629 198.4
10 ICH-352 71.84
4 ICH-229 54.73
3 ICH-173 51.31
20 ICH-661 49.6
21 ICH-69 49.6
9 ICH-347 46.18
6 ICH-246 44.47
18 ICH-544 41.05
14 ICH-439 37.63
2 ICH-139 35.92
7 ICH-32 35.92
8 ICH-341 35.92
1 ICH-137 35.06
11 ICH-376 35.06
13 ICH-400 34.21
16 ICH-467 34.21
17 ICH-478 34.21
15 ICH-444 32.5
12 ICH-391 30.79

daily_ast_lborres

Patients Values
9 ICH-242 391
5 ICH-155 284
30 ICH-632 265
31 ICH-673 228
4 ICH-145 178
18 ICH-435 157
26 ICH-514 156
15 ICH-383 154
29 ICH-629 151
21 ICH-450 145
16 ICH-400 144
17 ICH-41 144
23 ICH-478 142
20 ICH-449 138
34 ICH-9 134
12 ICH-31 132
28 ICH-578 128.5
2 ICH-121 128
11 ICH-307 128
14 ICH-357 125
3 ICH-138 122
1 ICH-10 121
7 ICH-184 120
33 ICH-69 119.5
13 ICH-332 110
22 ICH-464 108
6 ICH-157 107
24 ICH-490 107
25 ICH-511 107
8 ICH-237 101
27 ICH-529 101
32 ICH-68 99
10 ICH-26 98
19 ICH-438 98

daily_bun_lborres

Patients Values
19 ICH-347 44.53
14 ICH-263 41.99
21 ICH-357 39.6
23 ICH-367 35.7
37 ICH-52 32.2
49 ICH-72 32.02
45 ICH-629 31.27
15 ICH-270 31.24
1 ICH-116 30.42
10 ICH-191 27.84
39 ICH-526 26.97
4 ICH-140 26.73
8 ICH-188 26.31
12 ICH-204 25.79
35 ICH-461 24.52
50 ICH-73 24.2
7 ICH-173 23.76
13 ICH-208 23.16
3 ICH-126 22.3
42 ICH-595 20.91
34 ICH-45 20.83
32 ICH-446 20.8
5 ICH-16 20.11
38 ICH-523 19.93
48 ICH-67 19.81
31 ICH-438 19.78
20 ICH-351 19.76
24 ICH-370 19.75
36 ICH-476 18.98
28 ICH-42 18.92
2 ICH-120 18.9
22 ICH-365 18.25
26 ICH-400 18.23
41 ICH-574 18.19
27 ICH-416 17.9
46 ICH-642 17.87
9 ICH-190 17.27
18 ICH-340 17.27
16 ICH-29 17.1
33 ICH-447 17.1
40 ICH-527 17.08
25 ICH-394 17.05
30 ICH-434 16.98
43 ICH-598 16.95
6 ICH-17 16.87
44 ICH-600 16.78
11 ICH-200 16.7
47 ICH-664 16.63
17 ICH-319 16.55
29 ICH-423 16.28

daily_creat_lborres

Patients Values
13 ICH-263 943.2
23 ICH-370 860.1
35 ICH-642 762.9
21 ICH-365 748.8
18 ICH-351 662.1
15 ICH-330 532.2
9 ICH-204 528.6
36 ICH-72 481.8
17 ICH-347 430.5
20 ICH-357 381.9
6 ICH-173 323.6
1 ICH-126 285.5
29 ICH-461 266.5
27 ICH-447 266.1
24 ICH-384 255.5
31 ICH-52 238.7
26 ICH-438 233.4
2 ICH-140 229
8 ICH-191 228.1
4 ICH-157 216.6
32 ICH-569 212.6
7 ICH-190 203.3
37 ICH-73 195.4
5 ICH-17 194.5
19 ICH-352 193.6
11 ICH-246 187.4
3 ICH-151 186.5
22 ICH-367 184.8
34 ICH-629 183.9
16 ICH-340 173.3
10 ICH-228 170.6
28 ICH-45 167.1
14 ICH-270 164.4
30 ICH-476 162.7
12 ICH-25 159.1
25 ICH-400 154.7
33 ICH-593 149.4

daily_sodium_lborres

Patients Values
7 ICH-270 183
16 ICH-45 168
14 ICH-416 165
8 ICH-279 160
19 ICH-595 160
11 ICH-400 156
18 ICH-571 156
17 ICH-531 153.5
22 ICH-74 153
1 ICH-100 151.5
4 ICH-208 151
20 ICH-600 150
2 ICH-163 149
3 ICH-188 149
10 ICH-357 149
21 ICH-69 131.5
5 ICH-242 131
12 ICH-405 131
13 ICH-41 131
15 ICH-443 127
9 ICH-323 126
6 ICH-263 124

daily_potassium_lborres

Patients Values
7 ICH-351 5.9
8 ICH-357 5.9
3 ICH-229 5.7
6 ICH-324 5.6
11 ICH-539 5.6
4 ICH-24 5.5
5 ICH-246 5.5
1 ICH-111 5.4
9 ICH-370 5.4
10 ICH-432 5.4
2 ICH-116 5.3
12 ICH-642 5.3
13 ICH-81 2.6

daily_crp_lborres

Patients Values
7 ICH-67 562.9
4 ICH-376 490.6
3 ICH-25 468.4
2 ICH-157 440.6
5 ICH-446 426.6
1 ICH-12 395.1
6 ICH-530 370.1

daily_crekin_lborres

Patients Values
36 ICH-514 3595
24 ICH-357 3011
1 ICH-10 2998
19 ICH-302 2408
30 ICH-471 2384
23 ICH-344 2194
31 ICH-474 1197
15 ICH-228 1121
38 ICH-532 1110
46 ICH-630 1108
29 ICH-461 1100
4 ICH-112 1072
47 ICH-636 1044
49 ICH-96 1039
17 ICH-237 990
5 ICH-131 939
9 ICH-169 919
48 ICH-69 877
45 ICH-620 826
22 ICH-332 814
35 ICH-505 785
39 ICH-538 784
37 ICH-526 766
27 ICH-447 765
28 ICH-458 763
33 ICH-478 749
41 ICH-558 713
7 ICH-140 709
10 ICH-186 679
16 ICH-230 626
26 ICH-445 607
13 ICH-208 598
11 ICH-190 587
40 ICH-540 582
12 ICH-20 581
3 ICH-105 575
8 ICH-16 568.5
44 ICH-613 544
43 ICH-600 540
6 ICH-139 539
34 ICH-50 527
32 ICH-475 514
14 ICH-225 510
2 ICH-103 507
42 ICH-591 501
25 ICH-4 496
21 ICH-321 485
18 ICH-25 480
20 ICH-317 477

SymptomsDays

Patients Values
1 ICH-141 41
13 ICH-655 39
4 ICH-166 33
2 ICH-142 30
8 ICH-285 26
9 ICH-366 24
14 ICH-92 24
7 ICH-233 23
5 ICH-196 22
12 ICH-550 22
10 ICH-410 21
11 ICH-451 21
6 ICH-197 20
3 ICH-161 19
15 ICH-99 19

comorbidities

Patients Values
1 ICH-108 1
22 ICH-237 1
30 ICH-270 1
33 ICH-299 1
34 ICH-314 1
36 ICH-330 1
39 ICH-345 1
41 ICH-404 1
43 ICH-411 1
45 ICH-446 1
47 ICH-461 1
48 ICH-462 1
50 ICH-480 1
53 ICH-527 1
59 ICH-570 1
60 ICH-576 1
61 ICH-583 1
62 ICH-587 1
65 ICH-591 1
67 ICH-614 1
69 ICH-632 1
70 ICH-636 1
72 ICH-660 1
75 ICH-73 1
76 ICH-75 1
2 ICH-11 0.5
3 ICH-111 0.5
4 ICH-12 0.5
5 ICH-121 0.5
6 ICH-125 0.5
7 ICH-137 0.5
8 ICH-142 0.5
9 ICH-15 0.5
10 ICH-151 0.5
11 ICH-159 0.5
12 ICH-165 0.5
13 ICH-171 0.5
14 ICH-185 0.5
15 ICH-204 0.5
16 ICH-205 0.5
17 ICH-211 0.5
18 ICH-216 0.5
19 ICH-219 0.5
20 ICH-224 0.5
21 ICH-235 0.5
23 ICH-238 0.5
24 ICH-24 0.5
25 ICH-242 0.5
26 ICH-244 0.5
27 ICH-26 0.5
28 ICH-263 0.5
29 ICH-265 0.5
31 ICH-284 0.5
32 ICH-29 0.5
35 ICH-317 0.5
37 ICH-343 0.5
38 ICH-344 0.5
40 ICH-37 0.5
42 ICH-41 0.5
44 ICH-432 0.5
46 ICH-45 0.5
49 ICH-478 0.5
51 ICH-489 0.5
52 ICH-509 0.5
54 ICH-543 0.5
55 ICH-55 0.5
56 ICH-554 0.5
57 ICH-569 0.5
58 ICH-57 0.5
63 ICH-59 0.5
64 ICH-590 0.5
66 ICH-595 0.5
68 ICH-62 0.5
71 ICH-648 0.5
73 ICH-67 0.5
74 ICH-69 0.5
77 ICH-77 0.5
78 ICH-79 0.5
79 ICH-82 0.5
80 ICH-85 0.5

GlobalSurvival

Patients Values
1 ICH-141 45
3 ICH-200 45
2 ICH-185 44
4 ICH-337 43
5 ICH-655 43
6 ICH-98 43

hodur

Patients Values
ICH-673 34.2

Italian

age_estimateyears

Info
No observations with problems have been found

temp_vsorres

Patients Values
3 481-0022 40.5
7 481-0191 40.4
5 481-0093 40
6 481-0099 39.9
8 OMNI001-1005 39.8
9 OMNI001-226 39.8
12 OMNI001-777 39.8
1 481-0004 39.6
2 481-0011 39.4
4 481-0072 39.4
11 OMNI001-578 39.4
13 OMNI001-900 39.4
10 OMNI001-424 33.5

hr_vsorres

Patients Values
1 481-0003 170
12 OMNI001-128 160
4 481-0082 140
3 481-0081 137
10 ICH-523 132.2
2 481-0079 130
5 481-0102 130
14 OMNI001-303 130
15 OMNI001-510 130
17 OMNI001-97 130
9 481-0175 127
6 481-0120 126
7 481-0126 40
8 481-0171 40
16 OMNI001-603 40
13 OMNI001-270 36
11 OMNI001-1115 30

sysbp_vsorres

Patients Values
31 OMNI001-559 220
5 481-0075 210
6 481-0080 210
12 OMNI001-121 200
16 OMNI001-188 200
17 OMNI001-226 200
11 OMNI001-1015 190
15 OMNI001-172 190
18 OMNI001-253 190
19 OMNI001-261 190
26 OMNI001-498 188
10 OMNI001-1 185
21 OMNI001-38 185
24 OMNI001-434 185
27 OMNI001-509 185
28 OMNI001-535 181
2 481-0012 180
14 OMNI001-157 180
20 OMNI001-28 180
23 OMNI001-433 180
25 OMNI001-450 180
29 OMNI001-542 180
36 OMNI001-71 180
37 OMNI001-712 180
38 OMNI001-789 180
39 OMNI001-893 180
33 OMNI001-585 178
4 481-0064 175
8 ICH-443 175
9 ICH-542 175
30 OMNI001-550 175
34 OMNI001-594 175
35 OMNI001-623 175
1 481-0003 85
32 OMNI001-582 85
3 481-0027 80
13 OMNI001-13 80
22 OMNI001-424 80
7 ICH-27 78.33

admission_diabp_vsorres

Patients Values
11 OMNI001-1015 158
32 OMNI001-357 110
38 OMNI001-480 110
42 OMNI001-524 110
60 OMNI001-958 110
62 OMNI001-997 110
53 OMNI001-751 109
6 481-0145 105
13 OMNI001-1076 105
34 OMNI001-396 105
37 OMNI001-473 105
44 OMNI001-528 105
1 481-0004 100
2 481-0012 100
3 481-0074 100
4 481-0078 100
5 481-0097 100
14 OMNI001-1120 100
17 OMNI001-15 100
18 OMNI001-155 100
19 OMNI001-156 100
20 OMNI001-157 100
21 OMNI001-175 100
23 OMNI001-188 100
24 OMNI001-206 100
25 OMNI001-22 100
26 OMNI001-226 100
27 OMNI001-243 100
28 OMNI001-253 100
29 OMNI001-261 100
30 OMNI001-291 100
31 OMNI001-337 100
33 OMNI001-379 100
35 OMNI001-458 100
40 OMNI001-486 100
41 OMNI001-508 100
43 OMNI001-526 100
45 OMNI001-559 100
46 OMNI001-564 100
48 OMNI001-585 100
50 OMNI001-623 100
51 OMNI001-625 100
52 OMNI001-672 100
54 OMNI001-81 100
55 OMNI001-870 100
56 OMNI001-893 100
57 OMNI001-904 100
58 OMNI001-905 100
59 OMNI001-93 100
61 OMNI001-980 100
15 OMNI001-121 99
22 OMNI001-187 99
36 OMNI001-461 99
39 OMNI001-481 99
9 ICH-568 48.33
10 ICH-610 48.29
8 ICH-357 47
12 OMNI001-1051 45
7 ICH-173 40.12
16 OMNI001-13 40
47 OMNI001-582 40
49 OMNI001-604 36

daily_wbc_lborres

Patients Values
33 ICH-639 113.2
30 ICH-600 38.17
6 ICH-161 29.54
13 ICH-314 26.32
22 ICH-480 23.49
16 ICH-405 21.5
46 OMNI001-421 21.25
53 OMNI001-679 21.14
9 ICH-229 20.5
25 ICH-52 20.19
10 ICH-233 20.07
43 OMNI001-179 20.05
26 ICH-523 19.85
17 ICH-416 19.56
20 ICH-465 19.46
37 OMNI001-1009 19.15
15 ICH-34 19.12
36 OMNI001-1006 19.1
32 ICH-629 19.04
7 ICH-163 18.59
51 OMNI001-509 18.43
8 ICH-164 18.22
40 OMNI001-152 17.55
11 ICH-246 17.49
24 ICH-505 17.14
18 ICH-435 17.12
49 OMNI001-455 17.06
4 ICH-147 16.87
41 OMNI001-157 16.52
2 481-0029 16.4
45 OMNI001-384 16.16
56 OMNI001-97 16.14
44 OMNI001-38 16.06
57 OMNI001-994 16.04
42 OMNI001-166 16
5 ICH-160 15.84
19 ICH-447 15.82
31 ICH-616 15.78
27 ICH-538 15.73
21 ICH-48 15.71
29 ICH-598 15.62
48 OMNI001-436 15.54
23 ICH-500 15.37
50 OMNI001-489 15.37
52 OMNI001-642 15.37
35 ICH-79 15.28
38 OMNI001-114 15.25
39 OMNI001-14 15.22
47 OMNI001-43 15.2
54 OMNI001-940 15.08
3 481-0096 14.9
28 ICH-544 14.46
14 ICH-316 14.42
12 ICH-282 14.38
34 ICH-78 14.35
1 481-0027 14.2
55 OMNI001-955 14.17

daily_lymp_lborres

Patients Values
11 ICH-161 12.3
14 ICH-233 9.5
37 OMNI001-517 8.31
1 481-0027 8
18 ICH-316 7.7
39 OMNI001-679 7.34
6 481-0194 5.3
19 ICH-361 4.4
42 OMNI001-994 4.39
10 ICH-147 4.35
7 481-0196 3.83
27 ICH-92 3.8
25 ICH-648 3.6
24 ICH-539 3.3
34 OMNI001-384 3.22
40 OMNI001-70 3.21
38 OMNI001-611 3.17
28 OMNI001-1009 3.15
30 OMNI001-157 3.07
29 OMNI001-152 3.01
36 OMNI001-516 3.01
2 481-0043 2.8
5 481-0181 2.8
23 ICH-503 2.8
8 ICH-126 2.7
16 ICH-275 2.7
26 ICH-66 2.7
17 ICH-314 2.65
4 481-0153 2.62
22 ICH-481 2.6
35 OMNI001-474 2.52
33 OMNI001-37 2.51
12 ICH-170 2.5
20 ICH-447 2.5
3 481-0074 2.4
9 ICH-142 2.4
13 ICH-231 2.4
15 ICH-264 2.4
21 ICH-464 2.4
31 OMNI001-191 2.39
32 OMNI001-208 2.39
41 OMNI001-91 2.39

daily_neutro_lborres

Patients Values
27 ICH-600 35
12 ICH-314 21.25
19 ICH-480 21
22 ICH-52 19.1
9 ICH-229 18.95
14 ICH-405 18.7
17 ICH-465 18.3
38 OMNI001-421 18.22
42 OMNI001-509 18.1
23 ICH-523 18
4 ICH-16 17.95
15 ICH-416 17.7
32 OMNI001-1006 17.14
29 ICH-629 17.1
10 ICH-246 16.2
6 ICH-161 16.1
7 ICH-163 16
13 ICH-34 15.65
40 OMNI001-455 15.58
8 ICH-164 15.4
21 ICH-505 15.25
33 OMNI001-1009 15.18
37 OMNI001-38 15.13
16 ICH-435 14.95
26 ICH-598 14.9
36 OMNI001-166 14.59
1 481-0029 14.5
24 ICH-538 14.3
46 OMNI001-97 14.28
43 OMNI001-642 14.05
18 ICH-48 13.9
5 ICH-160 13.7
25 ICH-544 13.6
41 OMNI001-489 13.54
31 ICH-79 13.3
35 OMNI001-14 13.26
39 OMNI001-43 13.19
34 OMNI001-114 13.18
2 481-0096 13.1
45 OMNI001-940 13.08
11 ICH-282 13.05
28 ICH-616 12.9
20 ICH-500 12.7
3 ICH-12 12.6
30 ICH-78 12.6
44 OMNI001-679 12.48

daily_haematocrit_lborres

Patients Values
11 ICH-515 53.4
15 OMNI001-1087 52.7
3 481-0096 52
18 OMNI001-471 51.3
20 OMNI001-575 25.5
21 OMNI001-631 25.2
2 481-0084 25
14 ICH-79 25
12 ICH-639 24.9
22 OMNI001-698 24.9
10 ICH-397 24.8
4 ICH-139 24.5
8 ICH-233 24.5
7 ICH-232 24.4
23 OMNI001-774 24.3
1 481-0068 24
5 ICH-171 24
9 ICH-317 23.7
6 ICH-173 22.95
16 OMNI001-1089 22.9
13 ICH-660 22.6
19 OMNI001-517 22.3
24 OMNI001-99 20.6
17 OMNI001-152 19.1

daily_plt_lborres

Patients Values
4 ICH-163 917
20 ICH-556 663
6 ICH-181 623
18 ICH-539 581
34 OMNI001-519 576
3 481-0150 570
11 ICH-398 542
17 ICH-503 524
9 ICH-229 520
32 OMNI001-188 513
28 ICH-92 492
26 ICH-73 484
21 ICH-557 480
30 OMNI001-1006 475
8 ICH-219 466
22 ICH-559 462
35 OMNI001-540 459
14 ICH-451 456
13 ICH-45 452
36 OMNI001-607 451
23 ICH-598 449
25 ICH-68 449
38 OMNI001-660 449
1 481-0055 446
5 ICH-168 444.5
2 481-0088 444
12 ICH-415 442
15 ICH-46 442
19 ICH-550 442
31 OMNI001-114 442
27 ICH-83 437
37 OMNI001-657 434
7 ICH-213 430
24 ICH-63 430
39 OMNI001-958 430
33 OMNI001-492 427
16 ICH-48 426
29 ICH-98 424.5
10 ICH-314 424

daily_creat_lborres

Patients Values
73 OMNI001-616 990.1
26 ICH-263 943.2
36 ICH-370 860.1
48 ICH-642 762.9
52 OMNI001-1114 751.4
34 ICH-365 748.8
76 OMNI001-656 680.7
79 OMNI001-724 680.7
31 ICH-351 662.1
85 OMNI001-999 636.5
64 OMNI001-477 601.1
55 OMNI001-13 539.3
28 ICH-330 532.2
22 ICH-204 528.6
51 OMNI001-11 503.9
49 ICH-72 481.8
71 OMNI001-583 450.8
30 ICH-347 430.5
67 OMNI001-509 415.5
12 481-0149 385
33 ICH-357 381.9
65 OMNI001-478 353.6
53 OMNI001-117 344.8
70 OMNI001-581 327.1
19 ICH-173 323.6
1 481-0003 320
63 OMNI001-463 309.4
14 ICH-126 285.5
42 ICH-461 266.5
40 ICH-447 266.1
77 OMNI001-678 265.2
37 ICH-384 255.5
4 481-0035 249
62 OMNI001-424 247.5
44 ICH-52 238.7
39 ICH-438 233.4
15 ICH-140 229
21 ICH-191 228.1
83 OMNI001-803 221
8 481-0085 221
6 481-0068 220
17 ICH-157 216.6
45 ICH-569 212.6
54 OMNI001-121 212.2
10 481-0115 212
20 ICH-190 203.3
56 OMNI001-152 203.3
75 OMNI001-622 203.3
50 ICH-73 195.4
18 ICH-17 194.5
61 OMNI001-354 194.5
32 ICH-352 193.6
24 ICH-246 187.4
16 ICH-151 186.5
58 OMNI001-176 185.6
35 ICH-367 184.8
47 ICH-629 183.9
72 OMNI001-603 176.8
74 OMNI001-620 176.8
9 481-0087 175
29 ICH-340 173.3
23 ICH-228 170.6
59 OMNI001-198 168
68 OMNI001-512 168
78 OMNI001-679 168
41 ICH-45 167.1
13 481-0177 165
27 ICH-270 164.4
43 ICH-476 162.7
5 481-0036 161
25 ICH-25 159.1
66 OMNI001-505 159.1
69 OMNI001-517 159.1
84 OMNI001-884 159.1
7 481-0080 159
11 481-0140 155
38 ICH-400 154.7
2 481-0017 151
57 OMNI001-166 150.3
60 OMNI001-210 150.3
80 OMNI001-727 150.3
81 OMNI001-777 150.3
82 OMNI001-789 150.3
46 ICH-593 149.4
3 481-0033 5.92

daily_sodium_lborres

Patients Values
21 ICH-270 183
28 ICH-45 168
26 ICH-416 165
7 481-0106 163
13 481-0149 163
22 ICH-279 160
31 ICH-595 160
25 ICH-400 156
30 ICH-571 156
6 481-0096 155
10 481-0126 155
29 ICH-531 153.5
5 481-0082 153
33 ICH-74 153
16 ICH-100 151.5
19 ICH-208 151
34 OMNI001-117 151
37 OMNI001-553 151
39 OMNI001-607 151
32 ICH-600 150
17 ICH-163 149
18 ICH-188 149
24 ICH-357 149
38 OMNI001-606 149
1 481-0004 130
2 481-0036 130
3 481-0052 130
4 481-0063 130
8 481-0109 130
15 481-0191 130
36 OMNI001-478 130
40 OMNI001-774 130
9 481-0116 128
11 481-0130 128
35 OMNI001-188 128
27 ICH-443 127
12 481-0134 126
23 ICH-323 126
20 ICH-263 124
14 481-0150 118

daily_potassium_lborres

Patients Values
29 OMNI001-188 6
42 OMNI001-724 6
14 ICH-351 5.9
15 ICH-357 5.9
35 OMNI001-540 5.9
2 481-0079 5.77
9 ICH-229 5.7
34 OMNI001-519 5.7
12 ICH-324 5.6
20 ICH-539 5.6
27 OMNI001-166 5.6
33 OMNI001-496 5.6
10 ICH-24 5.5
11 ICH-246 5.5
26 OMNI001-152 5.5
1 481-0035 5.46
6 ICH-111 5.4
16 ICH-370 5.4
19 ICH-432 5.4
36 OMNI001-603 5.4
37 OMNI001-616 5.4
7 ICH-116 5.3
21 ICH-642 5.3
24 OMNI001-1006 5.3
31 OMNI001-463 5.3
39 OMNI001-642 5.3
41 OMNI001-713 5.3
8 ICH-173 5.2
13 ICH-340 5.2
17 ICH-413 5.2
18 ICH-42 5.2
25 OMNI001-1115 5.2
28 OMNI001-179 5.2
30 OMNI001-205 5.2
38 OMNI001-630 5.2
40 OMNI001-658 5.2
4 481-0126 2.8
22 ICH-67 2.8
5 481-0134 2.67
23 ICH-81 2.6
32 OMNI001-467 2.6
3 481-0107 2.53

daily_crp_lborres

Patients Values
12 ICH-67 562.9
6 ICH-376 490.6
5 ICH-25 468.4
2 ICH-157 440.6
7 ICH-446 426.6
1 ICH-12 395.1
14 OMNI001-455 390.6
9 ICH-530 370.1
3 ICH-172 342.5
11 ICH-557 338.2
10 ICH-544 332.3
8 ICH-52 330.7
16 OMNI001-758 328
15 OMNI001-509 322
13 OMNI001-432 321.1
4 ICH-229 320.9

SymptomsDays

Patients Values
2 ICH-141 41
14 ICH-655 39
5 ICH-166 33
3 ICH-142 30
22 OMNI001-455 30
1 481-0074 29
18 OMNI001-152 29
21 OMNI001-334 29
9 ICH-285 26
17 OMNI001-114 25
10 ICH-366 24
15 ICH-92 24
8 ICH-233 23
6 ICH-196 22
13 ICH-550 22
11 ICH-410 21
12 ICH-451 21
23 OMNI001-461 21
24 OMNI001-486 21
25 OMNI001-542 21
7 ICH-197 20
20 OMNI001-234 20
26 OMNI001-955 20
4 ICH-161 19
16 ICH-99 19
19 OMNI001-213 19

comorbidities

Info
No observations with problems have been found

GlobalSurvival

Info
No observations with problems have been found

hodur

Patients Values
ICH-673 34.2

Correlation study - Numerical Variables

The correlation for numerical variables was calculated using Spearman’s correlation coefficient. The range of values is between -1 and 1, where -1 indicates a high negative correlation, 1 a high positive correlation and 0 no correlation.

Calabria
.

Humanitas
.

Italian
.

Correlation study - Qualitative Variables

The association between categorical variables (binary, nominal and ordinal) has been calculated using Cramer’s V, which takes values between 0 and 1. The closer the value is to 1, the stronger the association between the variables.

Values -1 are missing values. A different color has been indicated to differentiate them from the value 0.

Calabria
.

Humanitas
.

Italian
.

Correlation study - Numerical+Qualitative Variables

The association between categorical and numerical variables was calculated using the Kruskal Wallis test (non-parametric ANOVA). In the graph below, categorical variables are in rows and numerical variables are in columns. The values represented in the graph are 1 - P-Value obtained in the Kruskal-Wallis test. Therefore, the strongest associations are those with values close to 1.

Values -1 are missing values. A different color has been indicated to differentiate them from the value 0.

Calabria
.

Humanitas
.

Italian
.

Generating Binary - Qualitative Data

Next section we created a binary matrix from qualitative data using dummy variables. The matrix is used to perform future analyses.

PCA

Performing PCA to see sample distribution with their loading values using 5 components.

PCA - Variable related to each component

We study the analysis of variance using the next variables (not used to compute the PCA model): country, sex, age_estimateyears.qual, dsterm, SOURCE, dsstdtc, suppds_qval, oxygen_proccur, renal_proccur, other_cmoccur, siteid, core_addinfo, GlobalSurvival. Next table shows the relationship between each variable of study and the component. A significant P-Value indicates that components has a strong relation with the variable.

For merged databases, a bias per database could happen. In following sections we are going to study which variables are more related to that bias in order to fix it.

Calabria

Component sex age_estimateyears.qual dsterm GlobalSurvival
p1 1.101964e-06 2.158548e-03 1.061392e-05 1.035065e-01
p2 2.747553e-02 8.509823e-16 7.069971e-06 2.152062e-01
p3 6.103323e-01 7.973793e-01 3.131287e-05 4.24169e-02
p4 6.993118e-02 6.2369e-01 2.986621e-01 6.643516e-03
p5 7.42576e-01 2.394078e-01 1.120846e-01 3.896174e-01

Humanitas

Component sex age_estimateyears.qual dsterm GlobalSurvival
p1 9.058452e-04 8.868122e-02 7.819868e-07 8.736599e-08
p2 3.718755e-01 8.996885e-43 2.929889e-19 6.570425e-02
p3 8.196715e-01 2.194926e-01 7.93637e-01 9.314953e-02
p4 4.851985e-01 9.067645e-03 4.769431e-02 3.862405e-02
p5 2.144037e-02 8.676144e-02 2.081887e-02 9.103903e-01

Italian

Component sex age_estimateyears.qual dsterm SOURCE GlobalSurvival
p1 2.334617e-01 2.443827e-04 1.112276e-05 2.193097e-73 1.346425e-03
p2 8.064632e-06 1.997009e-34 2.628421e-37 8.633431e-04 1.655992e-10
p3 1.705051e-02 1.576118e-48 5.504972e-04 2.351981e-02 2.633189e-12
p4 7.809362e-02 1.206089e-07 2.185615e-02 1.679024e-02 6.362811e-01
p5 3.607853e-01 8.90772e-01 1.670359e-05 1.202468e-62 6.817418e-01

PCA - Scores/Loadings

Colored points represent observation and black points represent variables. For those variables that belong to the top 10 with the highest loading values, the name is displayed.

Calabria

sex

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.

age_estimateyears.qual

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.

dsterm

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.
.

Humanitas

sex

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.

age_estimateyears.qual

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.

dsterm

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.
.

Italian

sex

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.

age_estimateyears.qual

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.

dsterm

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.

SOURCE

comp1_vs_comp2
.
comp1_vs_comp3
.
comp1_vs_comp4
.
comp1_vs_comp5
.
comp2_vs_comp3
.
comp2_vs_comp4
.
comp2_vs_comp5
.
comp3_vs_comp4
.
comp3_vs_comp5
.
comp4_vs_comp5
.
.

PCA - Variables related to database BIAS

Next table shows, per each merged database, which variables are more related to create a bias between the different sources. P-value and Adj.P-Value are performed by a Chi2 test (for qualitative variables) and Kruscal-Wallis test (for numerical variables) against SOURCE (source variable). Next columns are the loading values each variable reach for each of the PCA components where the variable SOURCE has been found significant.

Adjusted P-Value has been perform by FDR method for all P-values at the same time (qualitative + numerical variables).

Italian

Variable p.value adj.p.value p1 p2 p3 p4 p5 Description
xray_prperf_v2 1.029e-221 3.137e-220 0.3155 0.02783 0.03581 0.02971 0.03873 Chest X-Ray performed?
xray_prperf_v2 1.029e-221 3.137e-220 0.3155 0.02783 0.03581 0.02971 0.03873 Chest X-Ray performed?
ct_prperf 2.522e-208 3.847e-207 0.3121 0.004716 0.03249 0.01166 0.01435 CT performed?
ct_prperf 2.522e-208 3.847e-207 0.3121 0.004716 0.03249 0.01166 0.01435 CT performed?
hoyn 1.11e-176 1.129e-175 0.2603 0.02386 0.01844 0.04262 0.2081 Was the patient admitted previously or transferred from any other facility during this illness episode?
hoyn 1.11e-176 1.129e-175 0.2603 0.02386 0.01844 0.04262 0.2081 Was the patient admitted previously or transferred from any other facility during this illness episode?
viralpneu_ceterm 1.489e-165 1.135e-164 0.2875 0.06242 0.0007619 0.04352 0.09972 Viral pneumonia/pneumonitis
viralpneu_ceterm 1.489e-165 1.135e-164 0.2875 0.06242 0.0007619 0.04352 0.09972 Viral pneumonia/pneumonitis
shortbreath_ceoccur_v2 9.493e-95 5.791e-94 0.2028 0.1084 0.02476 0.009574 0.2029 Shortness of breath (Dyspnea)
shortbreath_ceoccur_v2 9.493e-95 5.791e-94 0.2028 0.1084 0.02476 0.009574 0.2029 Shortness of breath (Dyspnea)
ards_ceterm 3.829e-37 1.947e-36 0.1436 0.1952 0.09027 0.1029 0.1487 Acute Respiratory Distress Syndrome
ards_ceterm 3.829e-37 1.947e-36 0.1436 0.1952 0.09027 0.1029 0.1487 Acute Respiratory Distress Syndrome
fatigue_ceoccur_v2 7.954e-32 3.466e-31 0.09507 0.02276 0.0217 0.1381 0.3383 Fatigue / Malaise
fatigue_ceoccur_v2 7.954e-32 3.466e-31 0.09507 0.02276 0.0217 0.1381 0.3383 Fatigue / Malaise
noninvasive_proccur 5.845e-23 2.228e-22 0.1175 0.2747 0.1075 0.03746 0.0359 Non-invasive ventilation? (Any)
noninvasive_proccur 5.845e-23 2.228e-22 0.1175 0.2747 0.1075 0.03746 0.0359 Non-invasive ventilation? (Any)
admission_diabp_vsorres 2.142e-22 7.685e-22 0.1244 0.02956 0.02376 0.05502 0.0154 Diastolic blood pressure on admission
comorbidities 1.473e-21 4.993e-21 0.08307 0.04434 0.03269 0.04749 0.003382 Quantity of comorbidities - (Former Smoker = 0.5)
oxygen_cmoccur 5.522e-18 1.684e-17 0.09519 0.1522 0.02224 0.05274 0.1708 Any Oxygen therapy?
oxygen_cmoccur 5.522e-18 1.684e-17 0.09519 0.1522 0.02224 0.05274 0.1708 Any Oxygen therapy?
sysbp_vsorres 8.854e-18 2.572e-17 0.1013 0.04323 0.036 0.01347 0.06547 Systolic blood pressure on admission
hr_vsorres 1.061e-17 2.942e-17 0.0968 0.03445 0.06553 0.06922 0.0169 Heart rate on admission
obesity_mhyn 2.974e-16 7.558e-16 0.09194 0.1001 0.02613 0.06794 0.1561 Obesity (as defined by clinical staff)
obesity_mhyn 2.974e-16 7.558e-16 0.09194 0.1001 0.02613 0.06794 0.1561 Obesity (as defined by clinical staff)
pronevent_prtrt 1.12e-15 2.628e-15 0.08088 0.2019 0.2744 0.01401 0.1709 Prone Positioning sometime?
pronevent_prtrt 1.12e-15 2.628e-15 0.08088 0.2019 0.2744 0.01401 0.1709 Prone Positioning sometime?
vomit_ceoccur_v2 5.237e-13 1.141e-12 0.08176 0.1278 0.1837 0.3844 0.07011 Vomiting / Nausea
vomit_ceoccur_v2 5.237e-13 1.141e-12 0.08176 0.1278 0.1837 0.3844 0.07011 Vomiting / Nausea
daily_lymp_lborres 4.952e-12 1.042e-11 0.03149 0.08159 0.03033 0.01035 0.06148 Lymphocyte count
daily_sodium_lborres 1.17e-10 2.379e-10 0.05789 0.008203 0.03605 0.04336 0.006232 Sodium
temp_vsorres 3.724e-09 7.327e-09 0.09434 0.03976 0.1454 0.005088 0.08081 Temperature on admission
daily_potassium_lborres 1.259e-08 2.399e-08 0.01174 0.06952 0.05681 0.006811 0.2129 Potassium
chronicneu_mhyn 7.036e-07 1.262e-06 0.04135 0.0004402 0.1565 0.05324 0.00177 Chronic neurological disorder
chronicneu_mhyn 7.036e-07 1.262e-06 0.04135 0.0004402 0.1565 0.05324 0.00177 Chronic neurological disorder
daily_creat_lborres 5.798e-05 0.000101 0.002505 0.1172 0.1827 0.1376 0.1573 Serum Creatinine
diarrhoea_ceoccur_v2 9.125e-05 0.0001504 0.01558 0.1087 0.2055 0.3974 0.07413 Diarrhoea
diarrhoea_ceoccur_v2 9.125e-05 0.0001504 0.01558 0.1087 0.2055 0.3974 0.07413 Diarrhoea
age_estimateyears 0.0001475 0.0002368 0.0403 0.1653 0.2167 0.08085 0.00413 Age
diabetes_mhyn_2 0.0003016 0.00046 0.03424 0.1355 0.1336 0.167 0.08532 Diabetes Mellitus
diabetes_mhyn_2 0.0003016 0.00046 0.03424 0.1355 0.1336 0.167 0.08532 Diabetes Mellitus
daily_crp_lborres 0.0007237 0.001077 0.04312 0.2353 0.1029 0.009282 0.02367 CRP
daily_haematocrit_lborres 0.0007494 0.001088 0.02726 0.06154 0.1022 0.07639 0.1858 Haematocrit
myalgia_ceoccur_v2 0.001797 0.002492 0.01721 0.0477 0.01943 0.1394 0.1251 Muscle aches (Myalgia)
myalgia_ceoccur_v2 0.001797 0.002492 0.01721 0.0477 0.01943 0.1394 0.1251 Muscle aches (Myalgia)
hypertension_mhyn 0.002861 0.003642 0.01681 0.2078 0.1315 0.1545 0.06154 140mmHg systolic or >90mmHg diastolic.>Hypertension
hypertension_mhyn 0.002861 0.003642 0.01681 0.2078 0.1315 0.1545 0.06154 140mmHg systolic or >90mmHg diastolic.>Hypertension
chronicpul_mhyn 0.002866 0.003642 0.02971 0.1242 0.1948 0.09106 0.04818 Chronic pulmonary disease (not asthma)
chronicpul_mhyn 0.002866 0.003642 0.02971 0.1242 0.1948 0.09106 0.04818 Chronic pulmonary disease (not asthma)
daily_plt_lborres 0.005534 0.00689 0.0395 0.02709 0.01716 0.05505 0.05054 Platelet Count
hodur 0.02203 0.02688 0.02084 0.01262 0.007189 0.1659 0.018 ICU or High Dependency Unit admission - If YES, total duration:
fever_ceoccur_v2 0.02558 0.03001 0.02194 0.01651 0.1576 0.00578 0.1459 History of fever
fever_ceoccur_v2 0.02558 0.03001 0.02194 0.01651 0.1576 0.00578 0.1459 History of fever
renal_mhyn 0.02833 0.032 0.02759 0.1081 0.2235 0.1689 0.1785 Chronic kidney disease
renal_mhyn 0.02833 0.032 0.02759 0.1081 0.2235 0.1689 0.1785 Chronic kidney disease
SymptomsDays 0.04667 0.05176 0.002712 0.03946 0.1313 0.005428 0.02441 How many days between first Symptoms and the Admission
malignantneo_mhyn 0.1141 0.1221 0.005219 0.03733 0.09247 0.02951 0.09199 5 years ago with no evidence of ongoing disease. Do not include non-melanoma skin cancers. Do not include benign growths or dysplasia.>Malignant neoplasm
malignantneo_mhyn 0.1141 0.1221 0.005219 0.03733 0.09247 0.02951 0.09199 5 years ago with no evidence of ongoing disease. Do not include non-melanoma skin cancers. Do not include benign growths or dysplasia.>Malignant neoplasm
daily_wbc_lborres 0.1469 0.1545 0.02212 0.1467 0.02013 0.01932 0.09664 WBC count
icu_hoterm 0.2844 0.2891 0.009265 0.2803 0.2558 0.04046 0.1038 ICU or High Dependency Unit admission?
icu_hoterm 0.2844 0.2891 0.009265 0.2803 0.2558 0.04046 0.1038 ICU or High Dependency Unit admission?
daily_neutro_lborres 0.3508 0.3508 0.02137 0.2183 0.03773 0.01243 0.09358 Neutrophil count

PCA Summary - T2 Hotelling

Hotelling’s T2-test is used for the detection of severe anomalies that can influence the creation of the PCA model. Confidence intervals at 0.95, 0.99 and 0.999 have been studied.

T2 score is an approximation and each observation have to be studied in order to remove or not from the analysis.

Calabria
.

Humanitas
.

Italian
.

PCA Summary - T2 - Outliers

In order to be more strict, only those patients that have a value two times greater than the specific confidence interval limit are detected as outliers (observation T2 value >= 2*CI value).

Calabria

0.95

ID Value
481-0003 18.16
481-0085 17.93
481-0087 15.15
481-0091 15.33
481-0125 14.35
481-0128 14.01
481-0130 21.59
481-0141 18.44
481-0174 15.94
481-0176 13.49
481-0190 12.58
481-0196 14.71

0.99

ID Value
481-0130 21.59

0.999

Info
No data for Calabria data base.

Humanitas

0.95

ID Value
ICH-113 16.96
ICH-160 12.39
ICH-173 17.93
ICH-177 12.94
ICH-182 23.79
ICH-193 19.1
ICH-215 16.19
ICH-231 15.13
ICH-26 15.18
ICH-263 24.81
ICH-294 12.89
ICH-330 23.82
ICH-34 15.75
ICH-340 16.47
ICH-343 12.25
ICH-344 12.63
ICH-351 14.38
ICH-356 21.17
ICH-357 12.36
ICH-401 12.65
ICH-405 24.77
ICH-439 19.6
ICH-45 13.78
ICH-465 12.79
ICH-476 16.3
ICH-480 15.26
ICH-481 12.44
ICH-484 20.41
ICH-490 14.36
ICH-511 12.81
ICH-52 28.77
ICH-523 13.51
ICH-560 12.18
ICH-569 15.12
ICH-590 19.67
ICH-591 13.41
ICH-600 19.33
ICH-608 20.61
ICH-642 13.37
ICH-665 16.27
ICH-73 15.72

0.99

ID Value
ICH-182 23.79
ICH-193 19.1
ICH-263 24.81
ICH-330 23.82
ICH-356 21.17
ICH-405 24.77
ICH-439 19.6
ICH-484 20.41
ICH-52 28.77
ICH-590 19.67
ICH-600 19.33
ICH-608 20.61

0.999

ID Value
ICH-52 28.77

Italian

0.95

ID Value
481-0004 21.1
481-0008 12.38
481-0010 13.86
481-0012 20.18
481-0023 12.47
481-0032 26.34
481-0040 20.44
481-0041 15.24
481-0043 12.4
481-0044 16.98
481-0052 13.24
481-0054 17.86
481-0055 20.8
481-0065 12.22
481-0072 12.07
481-0075 13.17
481-0091 23.79
481-0118 17.05
481-0136 12.52
ICH-116 12.13
ICH-231 12.3
ICH-253 13.77
ICH-26 17.98
ICH-263 14.62
ICH-330 27.17
ICH-34 12.31
ICH-356 13.36
ICH-357 14.48
ICH-365 13.64
ICH-370 14.94
ICH-405 16.03
ICH-427 15.19
ICH-447 15.23
ICH-45 16.33
ICH-465 17.88
ICH-484 12.93
ICH-52 21.43
ICH-560 14.07
ICH-591 12.72
ICH-629 22.56
ICH-72 16.19
ICH-73 17.73
OMNI001-1009 14.3
OMNI001-107 13.14
OMNI001-11 13.63
OMNI001-121 23.08
OMNI001-132 12.06
OMNI001-260 14.61
OMNI001-369 19.62
OMNI001-38 13.49
OMNI001-424 26.41
OMNI001-512 18.01
OMNI001-517 20.13
OMNI001-581 12.56
OMNI001-616 30.59
OMNI001-72 13.33
OMNI001-724 15.76
OMNI001-803 12.11
OMNI001-999 18.41

0.99

ID Value
481-0004 21.1
481-0012 20.18
481-0032 26.34
481-0040 20.44
481-0055 20.8
481-0091 23.79
ICH-330 27.17
ICH-52 21.43
ICH-629 22.56
OMNI001-121 23.08
OMNI001-369 19.62
OMNI001-424 26.41
OMNI001-517 20.13
OMNI001-616 30.59

0.999

ID Value
OMNI001-616 30.59

PCA Summary - T2 Contribution

Showed 0.99 confidence interval variable contribution. Next graph shows which variables are more related to classify the patient as an outlier. The patients that are shown are those with a value two times higher than the confidence interval limit at 0.99.

Calabria

V1
.
.

Humanitas

ICH-182
.

ICH-193
.

ICH-263
.

ICH-330
.

ICH-356
.

ICH-405
.

ICH-439
.

ICH-484
.

ICH-52
.

ICH-590
.

…

Only showed first 10 plots of 12 plots.
.

Italian

481-0004
.

481-0012
.

481-0032
.

481-0040
.

481-0055
.

481-0091
.

ICH-330
.

ICH-52
.

ICH-629
.

OMNI001-121
.

…

Only showed first 10 plots of 14 plots.
.

PCA Summary - T2 Contribution - Top 5 most influential variables

Next table shows a sorted frequency table where you can see which are the variables more related to outlier patients.

Calabria

Variable Freq in TOP 5
daily_gcs_lbyn_Yes 1
daily_nasaloxy_cmtrt_NO 1
daily_nasaloxy_cmtrt_YES 1
inotrop_cmtrt_NO 1
inotrop_cmtrt_YES 1

Humanitas

Variable Freq in TOP 5
jointpain_ceoccur_v2_NO 9
jointpain_ceoccur_v2_YES 9
myalgia_ceoccur_v2_NO 9
myalgia_ceoccur_v2_YES 9
chestpain_ceoccur_v2_NO 4
renal_mhyn_NO 4
daily_bun_lborres 2
daily_creat_lborres 2
renal_mhyn_YES 2
comorbidities 1
daily_inr_lborres 1
daily_neutro_lborres 1
daily_rr_vsorres 1
icu_hoterm_NO 1
rr_vsorres 1
smoking_mhyn_NeverSmoker 1
sysbp_vsorres 1
systolic_vsorres 1
vomit_ceoccur_v2_NO 1

Italian

Variable Freq in TOP 5
renal_mhyn_NO 8
renal_mhyn_YES 8
fatigue_ceoccur_v2_NO 7
fatigue_ceoccur_v2_YES 6
vomit_ceoccur_v2_NO 5
vomit_ceoccur_v2_YES 5
chronicpul_mhyn_NO 4
diarrhoea_ceoccur_v2_NO 4
obesity_mhyn_NO 4
obesity_mhyn_YES 4
ards_ceterm_NO 3
chronicpul_mhyn_YES 2
daily_creat_lborres 2
diarrhoea_ceoccur_v2_YES 2
daily_haematocrit_lborres 1
daily_neutro_lborres 1
diabetes_mhyn_2_NO 1
icu_hoterm_YES 1
myalgia_ceoccur_v2_NO 1
myalgia_ceoccur_v2_YES 1

PCA Summary - RSS

Sum of squares due to regression is used for the detection of subjects poorly explained by the model that are usually considered as moderate outliers. Confidence intervals at 0.95, 0.99 and 0.999 have been studied.

RSS score is an approximation and each observation have to be studied in order to remove or not from the analysis.

Calabria
.

Humanitas
.

Italian
.

PCA Summary - RSS - Outliers

In order to be more strict, only those patients that have a value two times greater than the specific confidence interval limit are detected as outliers (observation RSS value >= 2*CI value).

Calabria

0.95

Info
No data for Calabria data base.

0.99

Info
No data for Calabria data base.

0.999

Info
No data for Calabria data base.

Humanitas

0.95

ID Value
ICH-1 784.4
ICH-242 406.5
ICH-639 342.3

0.99

ID Value
ICH-1 784.4

0.999

ID Value
ICH-1 784.4

Italian

0.95

ID Value
481-0002 1167
ICH-639 470

0.99

ID Value
481-0002 1167
ICH-639 470

0.999

ID Value
481-0002 1167

PCA Summary - RSS Contribution

Showed 0.99 confidence interval variable contribution. Next graph shows which variables are more related to classify the patient as an outlier. The patients that are shown are those with a value two times higher than the confidence interval limit at 0.99.

Calabria

Info
No data for Calabria data base.

Humanitas

ICH-1
.
.

Italian

481-0002
.

ICH-639
.
.

PCA Summary - RSS Contribution - Top 5 most influential variables

Next table shows a sorted frequency table where you can see which are the variables more related to outlier patients.

Calabria

Info
No patients with problems related to RSS.

Humanitas

Variable Freq in TOP 5
bactpneu_ceterm_NO 1
cough_ceoccur_v2_2_YESproductive 1
daily_temp_vsorres 1
subjid_ 1
temp_vsorres 1

Italian

Variable Freq in TOP 5
daily_potassium_lborres 1
daily_wbc_lborres 1
fatigue_ceoccur_v2_YES 1
hr_vsorres 1
icu_hoterm_NO 1
malignantneo_mhyn_YES 1
noninvasive_proccur_NO 1
oxygen_cmoccur_NO 1
subjid_ 1
viralpneu_ceterm_NO 1

Summary Information

Calabria

Dataset statistics
Number of observations 144
Number of variables 114

Humanitas

Dataset statistics
Number of observations 498
Number of variables 68

Italian

Dataset statistics
Number of observations 1145
Number of variables 52

Save Process

Databases are saved in .RData and .xlsx format with their new colnames. Excel format does not save the same R class for each variable. We recommend to work with .RData files in case you want to do your own study.